| The binary endocardial appearance is a poor discriminator of Anderson-Fabry disease from familial hypertrophic cardiomyopathy. | |
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MedLine Citation:
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PMID: 18498962 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: We compared the frequency of a binary endocardial appearance in patients with hypertrophic cardiomyopathy (HCM) and Anderson-Fabry disease (AFD). BACKGROUND: A recent study suggested that a binary endocardial appearance is a highly sensitive and specific discriminator of AFD from other causes of hypertrophic cardiomyopathy (HCM). METHODS: Fourteen patients with AFD (55.4 +/- 9.9 years, 9 men) and 14 patients with HCM (57.2 +/- 10.9 years, 9 men) were randomly selected from a dedicated patient database. Two-dimensional echo images were blindly reviewed by 2 experienced echocardiographers. RESULTS: Maximum left ventricular (LV) wall thickness, LV end-systolic dimension, fractional shortening, and left atrial size were similar in the 2 patient groups. The LV end-diastolic dimension was smaller in patients with HCM (p = 0.04). A binary sign was present in 8 of 28 patients (29%). The sensitivity and specificity of the binary sign as a discriminator of AFD from HCM were 35% and 79%, respectively. A binary sign was present in only 1 patient with LV wall thickness <15 mm. CONCLUSIONS: The binary endocardial appearance lacks sufficient sensitivity and specificity to be used as an echocardiographic screening tool. |
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Authors:
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Stavros Kounas; Camelia Demetrescu; Antonios A Pantazis; Andre Keren; Philip J Lee; Derralynn Hughes; Atul Mehta; Perry Mark Elliott |
Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: Journal of the American College of Cardiology Volume: 51 ISSN: 1558-3597 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-05-23 Completed Date: 2008-06-25 Revised Date: 2009-03-27 |
Medline Journal Info:
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Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 2058-61 Citation Subset: AIM; IM |
Affiliation:
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Heart Hospital, University College London, London, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cardiomyopathy, Hypertrophic, Familial / ultrasonography* Diagnosis, Differential Double-Blind Method Echocardiography Endocardium / ultrasonography* Fabry Disease / ultrasonography* Female Heart Ventricles / ultrasonography Humans Hypertrophy, Left Ventricular / ultrasonography Male Middle Aged Observer Variation Sensitivity and Specificity |
| Comments/Corrections | |
Comment In:
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J Am Coll Cardiol. 2009 Mar 3;53(9):813-4; author reply 814-5
[PMID:
19245977
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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