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The biliary HCO3- umbrella: experimental evidence revisited.
MedLine Citation:
PMID:  22450897     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: To critically review most recent experimental evidence for the protective action of biliary HCO3 secretion against bile acid-induced bile duct damage and development of fibrosing cholangiopathy in humans and experimental animals. RECENT FINDINGS: Studies in human cholangiocytes in vitro indicate that a biliary HCO3 umbrella protects against bile acid-induced cholangiocyte damage and apoptosis in humans. The Cl/HCO3 exchanger, AE2, and an intact biliary glycocalyx appear crucial for its stability. Related studies with experimental animal models in vivo have to be interpreted with caution as humans and mice differ not only with regard to bile salt pool, but also their expression patterns of transport proteins and signalling molecules. SUMMARY: Adequate biliary HCO3 secretion may protect against bile salt-induced cholangiopathies. Future therapeutic strategies in biliary diseases will aim at stabilizing the biliary HCO3 umbrella.
Authors:
Ulrich Beuers; Luca Maroni; Ronald O Elferink
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-23
Journal Detail:
Title:  Current opinion in gastroenterology     Volume:  -     ISSN:  1531-7056     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8506887     Medline TA:  Curr Opin Gastroenterol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
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