Document Detail

A biliary HCO3- umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes.
MedLine Citation:
PMID:  21932391     Owner:  NLM     Status:  MEDLINE    
CONCLUSION: A biliary HCO3- umbrella protects human cholangiocytes against damage by bile acid monomers. An intact glycocalyx and adequate AE2 expression are crucial in this process. Defects of the biliary HCO3- umbrella may lead to the development of chronic cholangiopathies.
Simon Hohenester; Lucas Maillette de Buy Wenniger; Coen C Paulusma; Sandra J van Vliet; Douglas M Jefferson; Ronald P Oude Elferink; Ulrich Beuers
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  55     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-22     Completed Date:  2012-02-17     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  173-83     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American Association for the Study of Liver Diseases.
Tytgat Institute for Liver and Intestinal Research, Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
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MeSH Terms
Anion Transport Proteins / genetics,  metabolism
Antiporters / genetics,  metabolism
Apoptosis / drug effects,  physiology
Bile Acids and Salts / pharmacokinetics*,  toxicity*
Bile Duct Neoplasms
Bile Ducts, Intrahepatic / cytology,  drug effects*,  metabolism*
Cell Line, Tumor
Epithelial Cells / cytology,  drug effects,  metabolism
Extracellular Space / metabolism
Gene Knockdown Techniques
Glycocalyx / metabolism
Hydrogen-Ion Concentration / drug effects
Microscopy, Electron
Neuraminidase / pharmacology
Sodium Bicarbonate / pharmacology*
Reg. No./Substance:
0/AE2 anion exchanger; 0/Anion Transport Proteins; 0/Antiporters; 0/Bile Acids and Salts; 144-55-8/Sodium Bicarbonate; EC

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