| A bifunctional organometallic ruthenium drug with multiple modes of inducing apoptosis. | |
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MedLine Citation:
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PMID: 21437708 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The organometallic glutathione S-transferase inhibitor ruthenium(II) (ethacrynic acid-η(6)-benzylamide)(1,3,5-triaza-7-phosphaadamantane) dichloride, termed ethaRAPTA, has been demonstrated to induce apoptosis in the cisplatin-resistant MCF-7 breast cancer cell line. Probing the molecular basis of this activity suggests that the complex triggers multiple pathways toward apoptosis, including those involving endonuclease G, caspases, and c-Jun N-terminal kinase, which could provide a therapy for multi-drug-resistant tumors. Furthermore, the induction of heat shock protein 70 expression enhances selectivity of the complex for tumor cells, reducing the general toxicity. |
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Authors:
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Soumya Chatterjee; Ilaria Biondi; Paul J Dyson; Arindam Bhattacharyya |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-25 |
Journal Detail:
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Title: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry Volume: - ISSN: 1432-1327 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9616326 Medline TA: J Biol Inorg Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Environmental Science, University of Kalyani, Kalyani, 741235, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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