| {beta}arrestin1 represses diet-induced obesity. | |
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MedLine Citation:
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PMID: 21543334 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Diet-related obesity is a major metabolic disorder. Excessive fat mass is associated with type 2 diabetes, hepatic steatosis and arteriosclerosis. Dysregulation of lipid metabolism and adipose tissue function contributes to diet-induced obesity. Here, we report that βarrestin1 knockout mice are susceptible to diet-induced obesity. Knockout of the gene encoding βarrestin1 causes increased fat mass accumulation and decreased whole-body insulin sensitivity in mice fed with a high fat diet. In βarrestin1 knockout mice, we find disrupted food intake and energy expenditure, and increased macrophages infiltration in white adipose tissue. At the molecular level, βarrestin1 deficiency affects the expression of many lipid metabolic genes and inflammatory genes in adipose tissue. Consistently, transgenic over expression of βarrestin1 represses diet-induced obesity and improves glucose tolerance and systemic insulin sensitivity. Thus, our findings reveal that βarrestin1 plays a role in the metabolism regulation. |
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Authors:
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Le-Nan Zhuang; Wen-Xiang Hu; Ming-Liang Zhang; Shun-Mei Xin; Wei-Ping Jia; Jian Zhao; Gang Pei |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-4 |
Journal Detail:
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Title: The Journal of biological chemistry Volume: - ISSN: 1083-351X ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985121R Medline TA: J Biol Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Institute of Biochemistry and Cell Biology, China; |
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