Document Detail


On betaH-Leu5-endorphin and schizophrenia.
MedLine Citation:
PMID:  217315     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A previously unknown peptide, betaH-Leu5-endorphin, has been reported in the dialysates of schizophrenic patients. Accordingly, hemofiltrates from two schizophrenic and two control patients were examined for the presence of betaH-Leu5-endorphin. The opioid peptides were detected by a radioreceptor assay after separation and identification by gel filtration and high-performance liquid chromatography. With a detection limit of 30 pmole/L of hemofiltrate, no betaH-Leu5-endorphin or Met5-endorphin was found in controls or in patients. Whatever the possible involvement of endorphins in schizophrenic behavior, they are not present at detectable levels in the hemofiltrates of two well-characterized schizophrenic patients, thereby casting doubt on a general relationship of Leu-endorphin and schizophrenia.
Authors:
R V Lewis; L D Gerber; S Stein; R L Stephen; B I Grosser; S F Velick; S Udenfriend
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of general psychiatry     Volume:  36     ISSN:  0003-990X     ISO Abbreviation:  Arch. Gen. Psychiatry     Publication Date:  1979 Feb 
Date Detail:
Created Date:  1979-04-25     Completed Date:  1979-04-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372435     Medline TA:  Arch Gen Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  237-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Endorphins / blood*
Humans
Male
Receptors, Opioid / analysis
Renal Dialysis
Schizophrenia / blood*,  therapy
Chemical
Reg. No./Substance:
0/Endorphins; 0/Receptors, Opioid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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