| On betaH-Leu5-endorphin and schizophrenia. | |
| | |
MedLine Citation:
|
PMID: 217315 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A previously unknown peptide, betaH-Leu5-endorphin, has been reported in the dialysates of schizophrenic patients. Accordingly, hemofiltrates from two schizophrenic and two control patients were examined for the presence of betaH-Leu5-endorphin. The opioid peptides were detected by a radioreceptor assay after separation and identification by gel filtration and high-performance liquid chromatography. With a detection limit of 30 pmole/L of hemofiltrate, no betaH-Leu5-endorphin or Met5-endorphin was found in controls or in patients. Whatever the possible involvement of endorphins in schizophrenic behavior, they are not present at detectable levels in the hemofiltrates of two well-characterized schizophrenic patients, thereby casting doubt on a general relationship of Leu-endorphin and schizophrenia. |
| | |
Authors:
|
R V Lewis; L D Gerber; S Stein; R L Stephen; B I Grosser; S F Velick; S Udenfriend |
Related Documents
:
|
1438625 - Pupillary constriction during haloperidol treatment as a predictor of relapse following... 1114785 - Histocompatibility antigens in leprosy. 9323345 - No deficit in wisconsin card sorting test performance of schizophrenic patients' first-... 11440775 - Lower prolactin bioactivity in unmedicated schizophrenic patients. 21415815 - Relationship between increased systemic inflammation and impaired aortic elasticity in ... 19630775 - Factor xi deficiency in humans. |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Archives of general psychiatry Volume: 36 ISSN: 0003-990X ISO Abbreviation: Arch. Gen. Psychiatry Publication Date: 1979 Feb |
Date Detail:
|
Created Date: 1979-04-25 Completed Date: 1979-04-25 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0372435 Medline TA: Arch Gen Psychiatry Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 237-9 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Endorphins / blood* Humans Male Receptors, Opioid / analysis Renal Dialysis Schizophrenia / blood*, therapy |
| Chemical | |
Reg. No./Substance:
|
0/Endorphins; 0/Receptors, Opioid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cell killing by Simian virus 40: protective effect of chloroquine.
Next Document: Pancreatic lesion in newborn mice caused by Coxsackie B1 virus