Document Detail

On betaH-Leu5-endorphin and schizophrenia.
MedLine Citation:
PMID:  217315     Owner:  NLM     Status:  MEDLINE    
A previously unknown peptide, betaH-Leu5-endorphin, has been reported in the dialysates of schizophrenic patients. Accordingly, hemofiltrates from two schizophrenic and two control patients were examined for the presence of betaH-Leu5-endorphin. The opioid peptides were detected by a radioreceptor assay after separation and identification by gel filtration and high-performance liquid chromatography. With a detection limit of 30 pmole/L of hemofiltrate, no betaH-Leu5-endorphin or Met5-endorphin was found in controls or in patients. Whatever the possible involvement of endorphins in schizophrenic behavior, they are not present at detectable levels in the hemofiltrates of two well-characterized schizophrenic patients, thereby casting doubt on a general relationship of Leu-endorphin and schizophrenia.
R V Lewis; L D Gerber; S Stein; R L Stephen; B I Grosser; S F Velick; S Udenfriend
Related Documents :
1438625 - Pupillary constriction during haloperidol treatment as a predictor of relapse following...
1114785 - Histocompatibility antigens in leprosy.
9323345 - No deficit in wisconsin card sorting test performance of schizophrenic patients' first-...
11440775 - Lower prolactin bioactivity in unmedicated schizophrenic patients.
21415815 - Relationship between increased systemic inflammation and impaired aortic elasticity in ...
19630775 - Factor xi deficiency in humans.
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of general psychiatry     Volume:  36     ISSN:  0003-990X     ISO Abbreviation:  Arch. Gen. Psychiatry     Publication Date:  1979 Feb 
Date Detail:
Created Date:  1979-04-25     Completed Date:  1979-04-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372435     Medline TA:  Arch Gen Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  237-9     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Endorphins / blood*
Receptors, Opioid / analysis
Renal Dialysis
Schizophrenia / blood*,  therapy
Reg. No./Substance:
0/Endorphins; 0/Receptors, Opioid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Cell killing by Simian virus 40: protective effect of chloroquine.
Next Document:  Pancreatic lesion in newborn mice caused by Coxsackie B1 virus