Document Detail


beta2 adrenoceptor (ADRB2) pharmacogenetics and cardiovascular phenotypes during laryngoscopy and tracheal intubation.
MedLine Citation:
PMID:  17132602     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pharmacogenetics is the study of genetic variations that cause a variable drug response characterized by alteration in drug metabolism or in pharmacodynamics. The polymorphisms in genes encoding receptors relevant to treatment cause variation in sensitivity to many drugs. beta2 Adrenoceptor genetic variation contributes to regulation of blood pressure and hemodynamic changes by mediating peripheral vasodilatation. Laryngoscopy and tracheal intubation associated with hemodynamic changes. Although there are four nonsynomic single-nucleotide polymorphisms (SNPs) of beta2 adrenoceptor gene, codon 16 (Arg16Gly) and codon 27 (Gln27Glu) SNPs are both common and functionally important. In this paper, the authors investigated the beta2 adrenoceptor Gly16 and Glu27 SNPs in response to drugs relevant to anesthesia and how these SNPs impacted upon the cardiovascular phenotypes. The authors measured arterial systolic and diastolic blood pressure, heart rate, and rate-pressure product before induction of anesthesia and 1 min following laryngoscopy and tracheal intubation. Genomic DNA was amplified and genotyped using allele-specific polymerase chain reaction (ASPCR) and restriction fragment length polymorphism (RFLP) assays, respectively. When the authors compared hemodynamic results according to genotypes, the patients with Gln homozygote allele at codon 27 exhibited significant increase of heart rate than patients with Glu allele after laryngoscope and tracheal intubation.
Authors:
Cetin Kaymak; Neslihan Aygün Kocabaş; Emre Durmaz; Derya Oztuna
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of toxicology     Volume:  25     ISSN:  1091-5818     ISO Abbreviation:  Int. J. Toxicol.     Publication Date:    2006 Nov-Dec
Date Detail:
Created Date:  2006-11-29     Completed Date:  2007-02-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9708436     Medline TA:  Int J Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  443-9     Citation Subset:  IM    
Affiliation:
Department of Anesthesiology and Reanimation, Faculty of Medicine, Kirikkale University, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Blood Pressure / genetics
Female
Genotype
Heart Rate / genetics
Humans
Intubation, Intratracheal*
Laryngoscopy*
Male
Middle Aged
Pharmacogenetics
Phenotype
Polymorphism, Single Nucleotide
Receptors, Adrenergic, beta-2 / genetics*,  physiology*
Chemical
Reg. No./Substance:
0/Receptors, Adrenergic, beta-2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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