| beta2 adrenoceptor (ADRB2) pharmacogenetics and cardiovascular phenotypes during laryngoscopy and tracheal intubation. | |
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MedLine Citation:
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PMID: 17132602 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pharmacogenetics is the study of genetic variations that cause a variable drug response characterized by alteration in drug metabolism or in pharmacodynamics. The polymorphisms in genes encoding receptors relevant to treatment cause variation in sensitivity to many drugs. beta2 Adrenoceptor genetic variation contributes to regulation of blood pressure and hemodynamic changes by mediating peripheral vasodilatation. Laryngoscopy and tracheal intubation associated with hemodynamic changes. Although there are four nonsynomic single-nucleotide polymorphisms (SNPs) of beta2 adrenoceptor gene, codon 16 (Arg16Gly) and codon 27 (Gln27Glu) SNPs are both common and functionally important. In this paper, the authors investigated the beta2 adrenoceptor Gly16 and Glu27 SNPs in response to drugs relevant to anesthesia and how these SNPs impacted upon the cardiovascular phenotypes. The authors measured arterial systolic and diastolic blood pressure, heart rate, and rate-pressure product before induction of anesthesia and 1 min following laryngoscopy and tracheal intubation. Genomic DNA was amplified and genotyped using allele-specific polymerase chain reaction (ASPCR) and restriction fragment length polymorphism (RFLP) assays, respectively. When the authors compared hemodynamic results according to genotypes, the patients with Gln homozygote allele at codon 27 exhibited significant increase of heart rate than patients with Glu allele after laryngoscope and tracheal intubation. |
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Authors:
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Cetin Kaymak; Neslihan Aygün Kocabaş; Emre Durmaz; Derya Oztuna |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of toxicology Volume: 25 ISSN: 1091-5818 ISO Abbreviation: Int. J. Toxicol. Publication Date: 2006 Nov-Dec |
Date Detail:
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Created Date: 2006-11-29 Completed Date: 2007-02-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9708436 Medline TA: Int J Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 443-9 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology and Reanimation, Faculty of Medicine, Kirikkale University, Turkey. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Blood Pressure / genetics Female Genotype Heart Rate / genetics Humans Intubation, Intratracheal* Laryngoscopy* Male Middle Aged Pharmacogenetics Phenotype Polymorphism, Single Nucleotide Receptors, Adrenergic, beta-2 / genetics*, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Adrenergic, beta-2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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