Document Detail


Beta2-adrenergic receptor genotype affects the renin-angiotensin-aldosterone system response to the Dietary Approaches to Stop Hypertension (DASH) dietary pattern.
MedLine Citation:
PMID:  20519561     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Beta(2)-adrenergic receptor (beta2-AR) is a susceptibility locus for hypertension, and polymorphisms at this site relate to salt sensitivity and low plasma renin activity (PRA). The Dietary Approaches to Stop Hypertension (DASH) dietary pattern lowers blood pressure and appears to interact with the renin-angiotensin-aldosterone system (RAAS).
OBJECTIVE: We hypothesized that the DASH diet associates with increased RAAS activity, and genotype status at beta2-AR G46A modifies this response.
DESIGN: We genotyped participants in the DASH-Sodium study (n = 372) at beta2-AR G46A to determine the association with blood pressure, RAAS components, and consumption of the DASH diet. We used 2-way mixed linear regression and an additive model for all primary analyses.
RESULTS: Mean (+/-SEM) PRA was significantly higher in participants in the DASH group than in participants in the control group (0.68 +/- 0.03 compared with 0.54 +/- 0.03 ng x mL(-1) x h(-1), P = 0.002). Serum aldosterone, urinary aldosterone, and urinary potassium concentrations were also significantly higher in the DASH group (P < 0.01 for all). We observed significant gene-diet interactions for changes in systolic blood pressure (SBP) and concentrations of aldosterone and urinary potassium (P for interaction = 0.048, 0.017, and 0.001 for SBP and aldosterone and urinary potassium concentrations, respectively). There was an association between the A allele of beta2-AR G46A and greater blood pressure reduction and blunted aldosterone and PRA responses to the DASH diet.
CONCLUSIONS: Our results indicate that the DASH diet lowers blood pressure and increases PRA and aldosterone concentrations. There is an association between the G46A polymorphism of beta2-AR and blood pressure and RAAS responses to the DASH diet, which suggests that beta2-AR may be a genetic modifier of DASH-diet responsiveness. This trial was registered at clinicaltrials.gov as NCT00000608.
Authors:
Bei Sun; Jonathan S Williams; Laura P Svetkey; Nikheel S Kolatkar; Paul R Conlin
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2010-06-02
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  92     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-21     Completed Date:  2010-08-12     Revised Date:  2011-08-03    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  444-9     Citation Subset:  AIM; IM    
Affiliation:
Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00000608
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MeSH Terms
Descriptor/Qualifier:
Aldosterone / blood,  genetics,  urine
Alleles
Blood Pressure
Diet*
Female
Genotype
Humans
Hypertension / diet therapy,  genetics*
Male
Middle Aged
Nutrigenomics*
Polymorphism, Single Nucleotide*
Potassium / urine
Receptors, Adrenergic, beta-2 / genetics*
Regression Analysis
Renin / blood,  genetics
Renin-Angiotensin System / genetics*
Grant Support
ID/Acronym/Agency:
K23 HL084236/HL/NHLBI NIH HHS; K23 HL084236-02/HL/NHLBI NIH HHS; K23 HL084236-05/HL/NHLBI NIH HHS; K24 DK63214/DK/NIDDK NIH HHS; R01 HL57114/HL/NHLBI NIH HHS; R01 HL77234/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Adrenergic, beta-2; 52-39-1/Aldosterone; 7440-09-7/Potassium; EC 3.4.23.15/Renin
Comments/Corrections

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