| Beta1,4-galactosyltransferase V regulates self-renewal of glioma-initiating cell. | |
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MedLine Citation:
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PMID: 20417617 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glioma results from unregulated expansion of a self-renewing glioma-initiating cell population. The regulatory pathways which are essential for sustaining the self-renewal of glioma-initiating cells remain largely unknown. Cell surface N-linked oligosaccharides play functional roles in determining cell fate and are associated with glioma malignancy. Previously, we have reported that beta1,4-galactosyltransferase V (beta1,4GalT V) effectively galactosylates the GlcNAcbeta1-->6Man arm of the highly branched N-glycans and positively regulates glioma cell growth. Here, we show that decreasing the expression of beta1,4GalT V by RNA interference in glioma cells attenuated the formation of polylactosamine and inhibited the ability of tumor formation in vivo. Down-regulation of beta1,4GalT V depleted CD133-positive cells in glioma xenograft, and inhibited the self-renewal capacity and the tumorigenic potential of glioma-initiating cells. These data reveal a critical role of beta1,4GalT V in the self-renewal and tumorigenicity of glioma-initiating cells, and indicate that manipulating beta1,4GalT V expression may have therapeutic potential for the treatment of malignant glioma. |
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Authors:
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Yuanyan Wei; Fengbiao Zhou; Yuqing Ge; Hong Chen; Chunhong Cui; Qiuping Li; Dan Liu; Zhiyuan Yang; Guoqiang Wu; Shuhui Sun; Jianxin Gu; Jianhai Jiang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-24 |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 396 ISSN: 1090-2104 ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-23 Completed Date: 2010-07-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
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Languages: eng Pagination: 602-7 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Key Laboratory of Glycoconjuates Research, Ministry of Public Health & Gene Research Center, Shanghai Medical College of Fudan University, Shanghai 200032, People's Republic of China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Sugars
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metabolism Animals Cell Line, Tumor Galactosyltransferases / genetics, physiology* Gene Knockdown Techniques Glioma / enzymology, pathology* Humans Mice Mice, Nude Neoplastic Stem Cells / enzymology, pathology* Polysaccharides / metabolism RNA, Small Interfering / genetics Xenograft Model Antitumor Assays |
| Chemical | |
Reg. No./Substance:
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0/Amino Sugars; 0/Polysaccharides; 0/RNA, Small Interfering; 100787-31-3/polylactosamine; EC 2.4.1.-/Galactosyltransferases; EC 2.4.1.-/beta-1,4-galactosyltransferase V |
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