Document Detail

The beta-agonist drug tulobuterol decreases cardiac automaticity in the rat: comparison with isoproterenol.
MedLine Citation:
PMID:  2858430     Owner:  NLM     Status:  MEDLINE    
The effect of the new beta-agonist drug tulobuterol, has been compared with isoproterenol in an experimental model of ectopic cardiac automaticity induced by local injury in the isolated right ventricle of the rat. Isoproterenol significantly increases ventricular automaticity even with the lowest concentrations tested (10(-9)M). Tulobuterol, at concentrations ranging from 10(-9)M to 10(-6)M do not induce any change on the automatic ventricular frequency. Nevertheless, at higher concentrations (10(-5) and 5 X 10(-5)M), tulobuterol decreases the experimentally induced ventricular automaticity. Our results suggest that the new beta-agonist drug tulobuterol does not increase ventricular automaticity but, in fact, decreases it.
M L Laorden; J Hernández; A J Brugger
Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  General pharmacology     Volume:  16     ISSN:  0306-3623     ISO Abbreviation:  Gen. Pharmacol.     Publication Date:  1985  
Date Detail:
Created Date:  1985-04-26     Completed Date:  1985-04-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7602417     Medline TA:  Gen Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  65-7     Citation Subset:  IM    
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MeSH Terms
Adrenergic beta-Agonists / pharmacology*
Arrhythmias, Cardiac / physiopathology
Heart / drug effects*
Isoproterenol / pharmacology*
Rats, Inbred Strains
Terbutaline / analogs & derivatives*,  pharmacology
Time Factors
Reg. No./Substance:
0/Adrenergic beta-Agonists; 23031-25-6/Terbutaline; 41570-61-0/tulobuterol; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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