Document Detail

The beta-adrenergic receptor in heart failure.
MedLine Citation:
PMID:  6138306     Owner:  NLM     Status:  MEDLINE    
Although the role of the autonomic nervous system in the pathophysiology of heart failure has been studied for decades, only within the past few years have adrenergic receptors and their alterations occupied center stage. There is now considerable evidence linking such receptors to many of the phenomena of heart failure; recent work appears to have significant therapeutic implications.
J A Heinsimer; R J Lefkowitz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Hospital practice (Office ed.)     Volume:  18     ISSN:  8750-2836     ISO Abbreviation:  Hosp. Pract. (Off. Ed.)     Publication Date:  1983 Nov 
Date Detail:
Created Date:  1983-12-17     Completed Date:  1983-12-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8404149     Medline TA:  Hosp Pract (Off Ed)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  103-9, 113-7, 121-5     Citation Subset:  AIM; IM    
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MeSH Terms
Adrenergic beta-Agonists / therapeutic use
Adrenergic beta-Antagonists / therapeutic use
Autonomic Nervous System / physiopathology
Binding Sites / drug effects
Catecholamines / metabolism
Heart / physiopathology
Heart Failure / drug therapy,  physiopathology*
Models, Biological
Myocardium / metabolism
Norepinephrine / physiology
Protein Binding / drug effects
Receptors, Adrenergic, alpha / analysis,  drug effects,  physiology
Receptors, Adrenergic, beta / analysis,  drug effects,  physiology*
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Adrenergic beta-Antagonists; 0/Catecholamines; 0/Ligands; 0/Receptors, Adrenergic, alpha; 0/Receptors, Adrenergic, beta; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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