| beta-Sheet mediated self-assembly of dipeptides of omega-amino acids and remarkable fibrillation in the solid state. | |
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MedLine Citation:
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PMID: 16010358 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Single crystal X-ray diffraction studies show that the extended structure of dipeptide Boc-beta-Ala-m-ABA-OMe (m-ABA: meta-aminobenzoic acid) self-assembles in the solid state by intermolecular hydrogen bonding to create an infinite parallel beta-sheet structure. In dipeptide Boc-gamma-Abu-m-ABA-OMe (gamma-Abu: gamma-aminobutyric acid), two such parallel beta-sheets are further cross-linked by intermolecular hydrogen bonding through m-aminobenzoic acid moieties. SEM (scanning electron microscopy) studies reveal that both the peptides and form amyloid-like fibrils in the solid state. The fibrils are also found to be stained readily by Congo red, a characteristic feature of the amyloid fiber whose accumulation causes several fatal diseases such as Alzheimer's, prion-protein etc. |
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Authors:
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Anita Dutt; Michael G B Drew; Animesh Pramanik |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-05-17 |
Journal Detail:
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Title: Organic & biomolecular chemistry Volume: 3 ISSN: 1477-0520 ISO Abbreviation: Org. Biomol. Chem. Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-07-12 Completed Date: 2005-11-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101154995 Medline TA: Org Biomol Chem Country: England |
Other Details:
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Languages: eng Pagination: 2250-4 Citation Subset: IM |
Affiliation:
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Department of Chemistry, University of Calcutta, 92, A. P. C. Road, Kolkata 700009, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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chemistry* Dipeptides / chemistry* Hydrogen Bonding Models, Molecular Molecular Structure Nuclear Magnetic Resonance, Biomolecular Spectrophotometry, Infrared |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Dipeptides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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