Document Detail

beta-Lactamase activity in Chromobacterium violaceum.
MedLine Citation:
PMID:  977998     Owner:  NLM     Status:  MEDLINE    
A strain of Chromobacterium violaceum isolated from a fatally infected patient was found to produce a beta-lactamase. When the organism was grown in drug-free medium, beta-lactamase activity was barely detectable, but when it was grown in the presence of penicillin G, a much larger amount of activity was produced. The beta lactamase was active primarily against cephalosporins; it was sensitive to inhibition by cloxacillin but resistant to p-chloromercuribenzoate. Thus this enzyme closely resembled the common type of beta-lactamase found in Pseudomonas aeruginosa. The organism was relatively susceptible to ticarcillin, carbenicillin, and cefoxitin, which resected hydrolysis by its beta-lactamase, but was quite resistant to 11 other beta-lactam antibiotics. Production of the beta-lactamase appeared to be mediated by chromosomal genes.
W E Farrar; N M O'dell
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  134     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1976 Sep 
Date Detail:
Created Date:  1976-12-23     Completed Date:  1976-12-23     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  290-3     Citation Subset:  AIM; IM    
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MeSH Terms
Cefoxitin / pharmacology
Cephalosporins / metabolism
Chloromercuribenzoates / pharmacology
Chromobacterium / drug effects,  enzymology*
Cloxacillin / pharmacology
Enzyme Induction
Middle Aged
Penicillin G
Penicillinase / biosynthesis,  metabolism*
Penicillins / pharmacology
Reg. No./Substance:
0/Cephalosporins; 0/Chloromercuribenzoates; 0/Penicillins; 35607-66-0/Cefoxitin; 61-33-6/Penicillin G; 61-72-3/Cloxacillin; EC 3.5.2.-/Penicillinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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