Document Detail


beta-Lactamase activity in Chromobacterium violaceum.
MedLine Citation:
PMID:  977998     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A strain of Chromobacterium violaceum isolated from a fatally infected patient was found to produce a beta-lactamase. When the organism was grown in drug-free medium, beta-lactamase activity was barely detectable, but when it was grown in the presence of penicillin G, a much larger amount of activity was produced. The beta lactamase was active primarily against cephalosporins; it was sensitive to inhibition by cloxacillin but resistant to p-chloromercuribenzoate. Thus this enzyme closely resembled the common type of beta-lactamase found in Pseudomonas aeruginosa. The organism was relatively susceptible to ticarcillin, carbenicillin, and cefoxitin, which resected hydrolysis by its beta-lactamase, but was quite resistant to 11 other beta-lactam antibiotics. Production of the beta-lactamase appeared to be mediated by chromosomal genes.
Authors:
W E Farrar; N M O'dell
Related Documents :
3488198 - Plasmid-mediated beta-lactamase in branhamella catarrhalis.
8654448 - Activity of beta-lactamase inhibitor combinations on escherichia coli isolates exhibiti...
12543688 - Emergence in klebsiella pneumoniae of a chromosome-encoded shv beta-lactamase that comp...
4942448 - Some relationships between r-factor and chromosomal -lactamase in gram-negative bacteria.
23275718 - Synonymous codon usage in forty staphylococcal phages identifies the factors controllin...
22736428 - Speckle tracking echocardiography in acute myocarditis.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  134     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1976 Sep 
Date Detail:
Created Date:  1976-12-23     Completed Date:  1976-12-23     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  290-3     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Cefoxitin / pharmacology
Cephalosporins / metabolism
Chloromercuribenzoates / pharmacology
Chromobacterium / drug effects,  enzymology*
Cloxacillin / pharmacology
Enzyme Induction
Genes
Humans
Male
Middle Aged
Penicillin G
Penicillinase / biosynthesis,  metabolism*
Penicillins / pharmacology
Chemical
Reg. No./Substance:
0/Cephalosporins; 0/Chloromercuribenzoates; 0/Penicillins; 35607-66-0/Cefoxitin; 61-33-6/Penicillin G; 61-72-3/Cloxacillin; EC 3.5.2.-/Penicillinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Synergism between amikacin and cefazolin against Klebsiella: in vitro studies and effect on the bact...
Next Document:  Distribution and characteristics of hepatitis B surface antigen in body fluids of institutionalized ...