| beta-D-Arabinofuran[1',2':4,5]oxazolo-1,3,5-triazine-5-N-methyl-4,6-dione and analogues, unusually specific immunosuppressive agents. | |
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MedLine Citation:
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PMID: 353281 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sequential treatment of the protected beta-D-arabinofuran[1',2':4,5]-2-aminooxazoline (2) with methyl isocyanate and diimidazole carbonyl afforded the 2,2'-anhydro-beta-D-arabinofuranosyl nucleoside, 6. Deprotection and hydrolysis yielded the corresponding arabinoside. Although the anhydronucleoside exhibited in vitro antiviral activity against herpes simplex type 1, it exacerbated the infection in vivo. Further examination uncovered an in vitro inhibition of the induction of a cell-mediated immune response without cytotoxicity. |
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Authors:
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W Wierenga; B E Loughman; A J Gibbons; H E Renis |
Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Journal of medicinal chemistry Volume: 21 ISSN: 0022-2623 ISO Abbreviation: J. Med. Chem. Publication Date: 1978 Jun |
Date Detail:
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Created Date: 1978-09-15 Completed Date: 1978-09-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9716531 Medline TA: J Med Chem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 558-62 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibody Formation / drug effects Antiviral Agents / chemical synthesis Cytotoxicity Tests, Immunologic Erythrocytes / immunology Hemolytic Plaque Technique Herpesviridae / drug effects Immunity / drug effects Immunity, Cellular / drug effects Immunosuppressive Agents / chemical synthesis* Isoantigens Mice Nucleotides, Cyclic / chemical synthesis*, pharmacology Spleen / immunology T-Lymphocytes / drug effects, immunology Triazines / chemical synthesis*, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 0/Immunosuppressive Agents; 0/Isoantigens; 0/Nucleotides, Cyclic; 0/Triazines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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