Document Detail


beta-D-Arabinofuran[1',2':4,5]oxazolo-1,3,5-triazine-5-N-methyl-4,6-dione and analogues, unusually specific immunosuppressive agents.
MedLine Citation:
PMID:  353281     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sequential treatment of the protected beta-D-arabinofuran[1',2':4,5]-2-aminooxazoline (2) with methyl isocyanate and diimidazole carbonyl afforded the 2,2'-anhydro-beta-D-arabinofuranosyl nucleoside, 6. Deprotection and hydrolysis yielded the corresponding arabinoside. Although the anhydronucleoside exhibited in vitro antiviral activity against herpes simplex type 1, it exacerbated the infection in vivo. Further examination uncovered an in vitro inhibition of the induction of a cell-mediated immune response without cytotoxicity.
Authors:
W Wierenga; B E Loughman; A J Gibbons; H E Renis
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Journal of medicinal chemistry     Volume:  21     ISSN:  0022-2623     ISO Abbreviation:  J. Med. Chem.     Publication Date:  1978 Jun 
Date Detail:
Created Date:  1978-09-15     Completed Date:  1978-09-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9716531     Medline TA:  J Med Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  558-62     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibody Formation / drug effects
Antiviral Agents / chemical synthesis
Cytotoxicity Tests, Immunologic
Erythrocytes / immunology
Hemolytic Plaque Technique
Herpesviridae / drug effects
Immunity / drug effects
Immunity, Cellular / drug effects
Immunosuppressive Agents / chemical synthesis*
Isoantigens
Mice
Nucleotides, Cyclic / chemical synthesis*,  pharmacology
Spleen / immunology
T-Lymphocytes / drug effects,  immunology
Triazines / chemical synthesis*,  pharmacology
Chemical
Reg. No./Substance:
0/Antiviral Agents; 0/Immunosuppressive Agents; 0/Isoantigens; 0/Nucleotides, Cyclic; 0/Triazines

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