Document Detail

beta-Bungarotoxin antagonizes the effect of alpha-latrotoxin from black widow spider venom on the neuromuscular junction.
MedLine Citation:
PMID:  6325594     Owner:  NLM     Status:  MEDLINE    
Sustained contraction of the chick biventer cervicis nerve-muscle preparations evoked by alpha-latrotoxin was antagonized quickly by beta-bungarotoxin. This effect of beta-bungarotoxin was dependent on its phospholipase A2 activity. In contrast, pancreatic phospholipase A2 was ineffective even at a much higher dose. It is concluded that alpha-latrotoxin needs intact presynaptic membrane to exert its effect.
M C Tzeng; S S Tian
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurobiology     Volume:  15     ISSN:  0022-3034     ISO Abbreviation:  J. Neurobiol.     Publication Date:  1984 Mar 
Date Detail:
Created Date:  1984-06-20     Completed Date:  1984-06-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0213640     Medline TA:  J Neurobiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  157-60     Citation Subset:  IM    
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MeSH Terms
Acetylcholine / metabolism
Arthropod Venoms / antagonists & inhibitors*
Bungarotoxins / pharmacology*
Muscle Contraction / drug effects
Muscles / innervation
Neuromuscular Junction / drug effects*
Spider Venoms / antagonists & inhibitors*,  pharmacology
Synaptic Transmission / drug effects*
Reg. No./Substance:
0/Arthropod Venoms; 0/Bungarotoxins; 0/Spider Venoms; 51-84-3/Acetylcholine; 65988-34-3/alpha-latrotoxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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