| Beta-amyloid, blood vessels, and brain function. | |
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MedLine Citation:
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PMID: 19443808 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cerebrovascular disease and Alzheimer disease are common diseases of aging and frequently coexist in the same brain. Accumulating evidence suggests that the presence of brain infarction, including silent infarction, influences the course of Alzheimer disease. Conversely, there is evidence that beta-amyloid can impair blood vessel function. Vascular beta-amyloid deposition, also known as cerebral amyloid angiopathy, is associated with vascular dysfunction in animal and human studies. Alzheimer disease is associated with morphological changes in capillary networks, and soluble beta-amyloid produces abnormal vascular responses to physiological and pharmacological stimuli. In this review, we discuss current evidence linking beta-amyloid metabolism with vascular function and morphological changes in animals and humans. |
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Authors:
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Eric E Smith; Steven M Greenberg |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2009-05-14 |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: 40 ISSN: 1524-4628 ISO Abbreviation: Stroke Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-30 Completed Date: 2009-07-27 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: United States |
Other Details:
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Languages: eng Pagination: 2601-6 Citation Subset: IM |
Affiliation:
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Division of Neurology, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alzheimer Disease
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metabolism,
physiopathology Amyloid beta-Peptides / metabolism* Animals Blood Vessels / metabolism* Brain / blood supply, physiology* Cerebral Amyloid Angiopathy / metabolism, physiopathology Cerebral Arteries / metabolism, physiopathology Humans |
| Grant Support | |
ID/Acronym/Agency:
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K23 NS046327-05/NS/NINDS NIH HHS; K24 NS056207/NS/NINDS NIH HHS; R01 AG021084/AG/NIA NIH HHS; R01 AG021084-02/AG/NIA NIH HHS; R01 AG026484/AG/NIA NIH HHS; R01 AG026484-04/AG/NIA NIH HHS; R01 NS042147/NS/NINDS NIH HHS; R01 NS062028/NS/NINDS NIH HHS; R01 NS062028-02/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amyloid beta-Peptides |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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