| Beta-alanine supplementation reduces acidosis but not oxygen uptake response during high-intensity cycling exercise. | |
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MedLine Citation:
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PMID: 19841932 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The oral ingestion of beta-alanine, the rate-limiting precursor in carnosine synthesis, has been shown to elevate the muscle carnosine content. Carnosine is thought to act as a physiologically relevant pH buffer during exercise but direct evidence is lacking. Acidosis has been hypothesised to influence oxygen uptake kinetics during high-intensity exercise. The present study aimed to investigate whether oral beta-alanine supplementation could reduce acidosis during high-intensity cycling and thereby affect oxygen uptake kinetics. 14 male physical education students participated in this placebo-controlled, double-blind study. Subjects were supplemented orally for 4 weeks with 4.8 g/day placebo or beta-alanine. Before and after supplementation, subjects performed a 6-min cycling exercise bout at an intensity of 50% of the difference between ventilatory threshold (VT) and VO(2peak). Capillary blood samples were taken for determination of pH, lactate, bicarbonate and base excess, and pulmonary oxygen uptake kinetics were determined with a bi-exponential model fitted to the averaged breath-by-breath data of three repetitions. Exercise-induced acidosis was significantly reduced following beta-alanine supplementation compared to placebo, without affecting blood lactate and bicarbonate concentrations. The time delay of the fast component (Td(1)) of the oxygen uptake kinetics was significantly reduced following beta-alanine supplementation compared to placebo, although this did not reduce oxygen deficit. The parameters of the slow component did not differ between groups. These results indicate that chronic beta-alanine supplementation, which presumably increased muscle carnosine content, can attenuate the fall in blood pH during high-intensity exercise. This may contribute to the ergogenic effect of the supplement found in some exercise modes. |
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Authors:
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Audrey Baguet; Katrien Koppo; Andries Pottier; Wim Derave |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2009-10-16 |
Journal Detail:
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Title: European journal of applied physiology Volume: 108 ISSN: 1439-6327 ISO Abbreviation: Eur. J. Appl. Physiol. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-20 Completed Date: 2010-04-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100954790 Medline TA: Eur J Appl Physiol Country: Germany |
Other Details:
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Languages: eng Pagination: 495-503 Citation Subset: IM |
Affiliation:
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Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acidosis
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metabolism,
physiopathology,
prevention & control* Adult Blood Gas Analysis Dietary Supplements Dose-Response Relationship, Drug Double-Blind Method Exercise / physiology* Exercise Test Humans Male Muscle, Skeletal / metabolism Oxygen Consumption / drug effects*, physiology Pulmonary Gas Exchange / physiology Time Factors beta-Alanine / administration & dosage, pharmacology* |
| Chemical | |
Reg. No./Substance:
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107-95-9/beta-Alanine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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