Document Detail

A benign tumour of the liver mimicking malignant liver disease--cholangiocellular adenoma.
MedLine Citation:
PMID:  19396663     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To describe three patients with liver lesions mimicking malignant tumours diagnosed finally, using contrast-enhanced ultrasound, as cholangiocellular adenoma (bile duct adenoma). MATERIAL AND METHODS: Focal liver lesions found incidentally in three patients. Contrast-enhanced ultrasound was with use of Siemens or Esaote equipment, low MI technique, after an intravenous bolus of 2.4 ml Sonovue (Bracco, Italy). RESULTS: Lesions were 9 mm, 15 mm and 20 mm in diameter and all were enhanced in the arterial phase and hypo-enhanced in the portal venous and late phases, suggesting their malignant nature. In two patients, no primary liver tumour was found, and in the third patient, previously resected for breast cancer, a tissue specimen was considered useful for characterizing tumour receptors for more targeted chemotherapy, the lesion being assumed metastatic in nature. Transcutaneous core biopsies were performed in all three patients. Pathological analysis (including the reference pathology) revealed cholangiocellular adenoma in all of them. CONCLUSION: Cholangiocellular adenoma is a rare entity and can be a reason for possible false malignant diagnosis using contrast-enhanced ultrasound. Follow-up examinations are recommended.
Andre Ignee; Fabio Piscaglia; Michaela Ott; Veronica Salvatore; Christoph F Dietrich
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  44     ISSN:  1502-7708     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  2009  
Date Detail:
Created Date:  2009-04-27     Completed Date:  2009-07-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  633-6     Citation Subset:  IM    
Department of Internal Medicine 2, Caritas Hospital Bad Mergentheim, Germany.
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MeSH Terms
Adenoma, Bile Duct / diagnosis,  pathology*,  ultrasonography
Bile Duct Neoplasms / pathology*,  ultrasonography
Bile Ducts, Intrahepatic*
Diagnosis, Differential
Image Enhancement / methods
Liver Neoplasms / diagnosis,  pathology*,  ultrasonography
Middle Aged
Phospholipids / diagnostic use
Risk Assessment
Sampling Studies
Sulfur Hexafluoride / diagnostic use
Ultrasonography, Doppler, Color
Reg. No./Substance:
0/Phospholipids; 0/contrast agent BR1; 2551-62-4/Sulfur Hexafluoride

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