Document Detail

The benefit of chemotherapy in a patient with multiple brain metastases and meningitis carcinomatosa from ovarian cancer.
MedLine Citation:
PMID:  15729605     Owner:  NLM     Status:  MEDLINE    
We report on a 45-year-old patient with stage IIIc ovarian cancer, multiple brain metastases, and meningitis carcinomatosa. After three courses of initial chemotherapy, consisting of docetaxel and carboplatin, the patient underwent interval cytoreductive surgery, consisting of hyster-ectomy, bilateral salpingo-oophorectomy, omentectomy, appendectomy, and retroperitoneal lymphadenectomy. Then five courses of the same chemotherapy were given as adjuvant treatment. At the completion of the primary therapy, she achieved a complete remission. Ten months after the completion of the initial treatment, multiple brain metastases with meningitis carcinomatosa were detected. After four courses of the same chemotherapy, she again had a complete response, confirmed by cranial enhanced magnetic resonance imaging (MRI), and she felt well, with relief from the debilitating neurologic symptoms for 4 months. After this 4 months, her disease recurred, with meningitis carcinomatosa, and she requested supportive care only. She died 4 months after this recurrence. Chemotherapy can help to prolong life for some patients with multiple brain metastases and meningitis carcinomatosa from ovarian cancer.
Ayako Watanabe; Muneaki Shimada; Junzo Kigawa; Takahiro Iba; Tetsuro Oishi; Yasunobu Kanamori; Naoki Terakawa
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  International journal of clinical oncology     Volume:  10     ISSN:  1341-9625     ISO Abbreviation:  Int. J. Clin. Oncol.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-02-24     Completed Date:  2005-05-24     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  9616295     Medline TA:  Int J Clin Oncol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  69-71     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Tottori University School of Medicine, 36-1 Nishimachi, Yonago, 683-8504, Japan.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Brain Neoplasms / complications,  drug therapy*,  secondary*
Carboplatin / administration & dosage
Carcinoma / complications,  drug therapy*,  secondary*
Fatal Outcome
Meningitis / drug therapy*
Middle Aged
Ovarian Neoplasms / complications,  drug therapy*,  pathology*,  surgery
Taxoids / administration & dosage
Reg. No./Substance:
0/Taxoids; 15H5577CQD/docetaxel; 41575-94-4/Carboplatin

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