| The beneficial and harmful effects of positive end expiratory pressure. | |
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MedLine Citation:
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PMID: 360447 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of increasing levels of positive end expiratory pressure on gas exchange and pulmonary mechanics were determined utilizing an ex vivo ventilated perfused canine pulmonary lobe. When zero positive end expiratory pressure was used, shunting, weight gain and a decrease in compliance occurred over the four and one-half hour experiment. Shunting was eliminated when 5, 10 or 15 centimeters of water of positive end expiratory pressure were used. However, increasing extravascular fluid sequestration and decreasing pulmonary compliance occurred progressively with increasing levels of positive end expiratory pressure above 5 centimeters of water. Pulmonary artery pressure increased immediately along with end inspiratory pressure, an amount approximately equal to the increase in positive end expiratory pressure, and this is thought to be the primary cause of the increased rate of fluid sequestration. These experiments suggest that an optimal level of positive end expiratory pressure exists when the shunt can be reduced and oxygenation improved without increasing the rate of extravascular fluid accumulation to the point where long time deleterious effects could outweigh immediate benefits. |
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Authors:
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T J Toung; P Saharia; W A Mitzner; S Permutt; J L Cameron |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Surgery, gynecology & obstetrics Volume: 147 ISSN: 0039-6087 ISO Abbreviation: Surg Gynecol Obstet Publication Date: 1978 Oct |
Date Detail:
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Created Date: 1978-12-27 Completed Date: 1978-12-27 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0101370 Medline TA: Surg Gynecol Obstet Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 518-24 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure Bronchopulmonary Sequestration / etiology Dogs Lung / pathology Lung Compliance Lung Volume Measurements Organ Size Positive-Pressure Respiration* / adverse effects Pulmonary Artery / physiology Pulmonary Circulation |
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