Document Detail

The beneficial effects of nettle supplementation and exercise on brain lesion and memory in rat.
MedLine Citation:
PMID:  19071007     Owner:  NLM     Status:  MEDLINE    
Regular swimming and phytotherapeutic supplementation are assumed to alleviate the severity of neurodegeneration leading to dementia. The effect of swimming training and that of enriched lab chow containing 1% (w/w) dried nettle (Urtica dioica) leaf on the prevention of severity of brain injury caused by N-methyl-d-aspartate (NMDA) lesion in Wistar rats were investigated. Nettle supplementation and regular swimming exercise seem to improve the adverse effect of brain injury caused by NMDA lesion assessed by passive avoidance test and open-field test. Nettle supplementation decreases the level of reactive oxygen species, measured by electron paramagnetic resonance, and the DNA-binding activity of NF-kappaB. The data reveal that nettle supplementation has an effective antioxidant role, down-regulates the inflammatory transcription factors and could also promote learning performance in the brain. Regular swimming increases the concentration of reactive species in the cerebellum and alters the activity of transcription factors toward inflammation. The additive effect of the two treatments was more profound in the down-regulation of inflammatory transcription processes in NMDA lesion.
Anna Toldy; Mustafa Atalay; Kriszti?n Stadler; M?ria Sasv?ri; Judit Jakus; Kyung J Jung; Hae Y Chung; Csaba Nyakas; Zsolt Rad?k
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Publication Detail:
Type:  Journal Article     Date:  2008-12-13
Journal Detail:
Title:  The Journal of nutritional biochemistry     Volume:  20     ISSN:  1873-4847     ISO Abbreviation:  J. Nutr. Biochem.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-16     Completed Date:  2010-02-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9010081     Medline TA:  J Nutr Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  974-81     Citation Subset:  IM    
Research Institute for Sport Sciences, Semmelweis University, 1123 Budapest, Hungary.
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MeSH Terms
Antioxidants / pharmacology*
Avoidance Learning / drug effects
Behavior, Animal / drug effects
Brain / metabolism
Cerebellum / metabolism
Free Radicals / metabolism
Inflammation / prevention & control
Memory / drug effects*
N-Methylaspartate / toxicity
Neurodegenerative Diseases / chemically induced,  prevention & control*
Oxidative Stress / drug effects
Physical Conditioning, Animal*
Rats, Wistar
Urtica dioica / chemistry*
Reg. No./Substance:
0/Antioxidants; 0/Free Radicals; 6384-92-5/N-Methylaspartate

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