Document Detail


The beneficial effect of nicardipine on the healing of myocardial infarcts in dogs.
MedLine Citation:
PMID:  6686768     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[2-(N-benzyl-N-methyl amino)] ethyl ester 5-methyl ester hydrochloride (nicardipine, RS-69216, YC-93), on the healing of myocardial infarcts has been examined in dogs surviving for 3 months after ligation of the left anterior descending coronary artery (LAD). Three groups of 12-14 dogs were subjected to the following treatments: a) Group X received one-month oral pretreatment (1-2 mg/kg/d) with post-ligation i.v. treatment delayed for 1 h (10 micrograms/kg followed by 2 micrograms/kg/15 min for 5 h) and oral treatment (1-2 mg/kg/d) for 3 months (n = 9 survivors). b) Group Y received oral placebo for one month, i.v. saline vehicle every 15 min for 5 h commencing 1 h postligation, and oral placebo for 3 months (n = 8 survivors). c) Group Z received oral placebo for one month as in group Y, i.v. and oral drug treatment post-ligation as for group X (n = 10 survivors). Recordings were made of general haemodynamics and at post mortem, each heart was X-rayed and sliced transversely to give 14 sections from which detailed observations were made on left ventricular (LV) geometry. Comparative morphological measurements were available from filed data for 11 normal dog hearts (designated group C) of similar type. Nicardipine treatment significantly modified the general haemodynamic responses to LAD ligation particularly in maintaining a low LV systolic pressure and inhibiting elevation of LV end diastolic pressure.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
B J Alps; C Calder; A Wilson; F M Scott-Park
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  33     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  1983  
Date Detail:
Created Date:  1984-03-01     Completed Date:  1984-03-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  1638-46     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects
Dogs
Hemodynamics / drug effects
Male
Myocardial Infarction / drug therapy*,  pathology,  physiopathology
Myocardium / pathology
Nicardipine
Nifedipine / analogs & derivatives*,  therapeutic use
Papillary Muscles / pathology
Chemical
Reg. No./Substance:
21829-25-4/Nifedipine; 55985-32-5/Nicardipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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