Document Detail

The behaviour of microsomal mono-electron carriers in adult and fetal liver and in placenta throughout pregnancy.
MedLine Citation:
PMID:  406759     Owner:  NLM     Status:  MEDLINE    
The activities and contents of microsomal mono-electron carriers (NADPH-cytochrome c reductase, NADH-cytochrome b5 reductase, cytochrome P-450 and cytochrome b5) in the liver of 160 pregnant rabbits and their response to phenobarbital (PB) administration were found to be different to that of non pregnant animals and to vary depending on the period of gestation. In fetal liver and in placenta the activities and contents of mixed function oxidase system enzymes are very low and increase from the mid-gestation up to the term of pregnancy. PB has either effect or decreases the enzyme levels. The variations of enzyme content and activity in maternal liver and the different response to PB are related to the hormonal modifications of pregnancy. The behaviour of mono-electron carriers in fetal liver can be related to the process of maturation of this organ. The effect of PB can be due to the interference of the drug with steroid metabolism. The behaviour of mixed function oxidase system enzymes in placenta can be related to the processes of maturation and ageing of organ.
P Paparella; F Castaldo; T Terranova; R Romor; A Bompiani
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  56     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  1977  
Date Detail:
Created Date:  1977-09-02     Completed Date:  1977-09-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  173-8     Citation Subset:  IM    
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MeSH Terms
Cytochrome P-450 Enzyme System / metabolism
Cytochrome Reductases / metabolism*
Cytochromes / metabolism*
Gestational Age
Liver / embryology,  enzymology*
Maternal-Fetal Exchange*
Microsomes / enzymology
NADPH-Ferrihemoprotein Reductase / metabolism
Phenobarbital / pharmacology
Placenta / enzymology*
Reg. No./Substance:
0/Cytochromes; 50-06-6/Phenobarbital; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.6.2.-/Cytochrome Reductases; EC Reductase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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