| The behaviour of BHK cells and neutrophil leukocytes on collagen gels of defined mechanical strength. | |
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MedLine Citation:
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PMID: 2126224 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study demonstrates how the mechanical strength of a series of collagen/composite gels can be measured using a penetrometer. It was found that the presence of fibrin in collagen gels resulted in increased gel strength. Similarly hyaluronic acid was found to increase the strength of collagen gels. Addition of heparin weakened collagen gels as did chondroitin-6-sulphate. Neutrophil migration into collagen gels was found to be inversely proportional to gel strength. Fibrin and hyaluronic acid containing gels inhibited neutrophil migration while the presence of heparin and chondroitin sulphate increased neutrophil migration. BHK gel contraction experiments demonstrated how the presence of fibrin prevents gel contraction. Despite increasing gel strength the presence of hyaluronic acid appeared to have no effect on BHK contraction of collagen gels. Similarly the presence of heparin or chondroitin sulphate had no effect on gel contraction by BHK cells. |
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Authors:
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G G Reid; J M Lackie; S D Gorham |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cell biology international reports Volume: 14 ISSN: 0309-1651 ISO Abbreviation: Cell Biol. Int. Rep. Publication Date: 1990 Nov |
Date Detail:
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Created Date: 1991-03-08 Completed Date: 1991-03-08 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7708050 Medline TA: Cell Biol Int Rep Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1033-45 Citation Subset: IM; S |
Affiliation:
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Department of Cell Biology, Glasgow University. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Line Cell Movement Cells, Cultured Chondroitin Sulfates Collagen Cricetinae Fibrin Fibroblasts / cytology* Gels Hyaluronic Acid Kidney Mesocricetus Neutrophils / cytology* Stress, Mechanical |
| Chemical | |
Reg. No./Substance:
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0/Gels; 9001-31-4/Fibrin; 9004-61-9/Hyaluronic Acid; 9007-28-7/Chondroitin Sulfates; 9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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