| The behavioral functions of the cholinergic basal forebrain: lessons from 192 IgG-saporin. | |
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MedLine Citation:
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PMID: 10198809 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Until recently our understanding of the functional neuroanatomy of the cholinergic basal forebrain (CBF) has been hindered by the lack of a lesioning technique that is truly selective. The development of the immunotoxin 192 IgG-saporin (192-sap) has greatly improved our ability to create specific lesions of the CBF. Rats with such lesions have been studied in a wide variety of behavioral paradigms of learning, memory, and attention. Complete or near-complete destruction of the CBF results in deficits in a variety of behavior paradigms including passive avoidance, spatial tasks (water and radial mazes), delayed matching to position/sample, and attentional tasks. However, interpretation of many experiments is hampered by incomplete lesions and/or concomitant damage to cerebellar Purkinje neurons. Future studies will need to address these issues. Recent development of a similar immunotoxin that is effective in primates should permit more sophisticated behavioral analysis of CBF function. Additionally, immunotoxins selective for other types of neurons, such as the noradrenergic selective anti-DBH-saporin, will permit analysis of the behavioral functions of other diffusely projecting systems and how these other systems may interact with the CBF. |
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Authors:
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C C Wrenn; R G Wiley |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience Volume: 16 ISSN: 0736-5748 ISO Abbreviation: Int. J. Dev. Neurosci. Publication Date: 1998 Nov-Dec |
Date Detail:
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Created Date: 1999-07-07 Completed Date: 1999-07-07 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8401784 Medline TA: Int J Dev Neurosci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 595-602 Citation Subset: IM |
Affiliation:
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Laboratory of Experimental Neurology, Department of Veterans Affairs, Nashville, TN 37212, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Monoclonal / toxicity* Attention / drug effects* Cholinergic Agents / toxicity* Immunotoxins / toxicity* Injections, Intraventricular Learning / drug effects* Memory / drug effects N-Glycosyl Hydrolases Prosencephalon / drug effects* Receptor, Nerve Growth Factor Receptors, Nerve Growth Factor / immunology Ribosome Inactivating Proteins, Type 1 |
| Chemical | |
Reg. No./Substance:
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0/192 IgG-saporin; 0/Antibodies, Monoclonal; 0/Cholinergic Agents; 0/Immunotoxins; 0/Receptor, Nerve Growth Factor; 0/Receptors, Nerve Growth Factor; 0/Ribosome Inactivating Proteins, Type 1; EC 3.2.2.-/N-Glycosyl Hydrolases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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