| The behavioral actions of lithium in rodent models: leads to develop novel therapeutics. | |
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MedLine Citation:
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PMID: 17532044 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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For nearly as long as lithium has been in clinical use for the treatment of bipolar disorder, depression, and other conditions, investigators have attempted to characterize its effects on behaviors in rodents. Lithium consistently decreases exploratory activity, rearing, aggression, and amphetamine-induced hyperlocomotion; and it increases the sensitivity to pilocarpine-induced seizures, decreases immobility time in the forced swim test, and attenuates reserpine-induced hypolocomotion. Lithium also predictably induces conditioned taste aversion and alterations in circadian rhythms. The modulation of stereotypy, sensitization, and reward behavior are less consistent actions of the drug. These behavioral models may be relevant to human symptoms and to clinical endophenotypes. It is likely that the actions of lithium in a subset of these animal models are related to the therapeutic efficacy, as well the side effects, of the drug. We conclude with a brief discussion of various molecular mechanisms by which these lithium-sensitive behaviors may be mediated, and comment on the ways in which rat and mouse models can be used more effectively in the future to address persistent questions about the therapeutically relevant molecular actions of lithium. |
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Authors:
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Kelley C O'Donnell; Todd D Gould |
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Publication Detail:
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Type: Journal Article; Review Date: 2007-04-13 |
Journal Detail:
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Title: Neuroscience and biobehavioral reviews Volume: 31 ISSN: 0149-7634 ISO Abbreviation: Neurosci Biobehav Rev Publication Date: 2007 |
Date Detail:
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Created Date: 2007-08-27 Completed Date: 2007-11-21 Revised Date: 2010-09-16 |
Medline Journal Info:
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Nlm Unique ID: 7806090 Medline TA: Neurosci Biobehav Rev Country: United States |
Other Details:
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Languages: eng Pagination: 932-62 Citation Subset: IM |
Affiliation:
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The Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH, HHS, Bldg 35, Rm 1C-912, 35 Convent Drive, Bethesda, MD 20892 3711, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Behavior, Animal / drug effects* Bipolar Disorder / drug therapy Depressive Disorder / drug therapy Disease Models, Animal Humans Lithium Compounds / pharmacology*, therapeutic use Mice Mice, Inbred Strains Rats Rats, Inbred Strains Species Specificity |
| Grant Support | |
ID/Acronym/Agency:
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NIH0010875152//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Lithium Compounds |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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