Document Detail


The behavior and routes of lead exposure in pregrasping infants.
MedLine Citation:
PMID:  15254477     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Understanding the routes of lead exposure in a very young infant is an essential precursor to identifying effective strategies for minimizing blood-lead (PbB) levels throughout infancy. The present study integrated observational data, lead-loading data, and household airborne particulate levels <10 microm (PM(10)) to understand the broad patterns of lead exposure in infants from Port Pirie, South Australia. Seven, 2-19-week-old infants were observed between three and six times, for 3-9 h per visit, at intervals of 1-9 weeks. Household lead-loading and PM(10) data were collected for five of the families. Eight objects were observed in an infant's mouth, but only the infant's fingers, pacifier, and nipple of the mother's breast or teat of a bottle were observed in an infant's mouth for an average of more than 1% of an observation day. The objects most frequently put in an infant's mouth were their own fingers or their pacifier. Synthesizing our data on behavioral frequency, lead loading, and the surface area of contact, and using estimates of dose response, and sampling, transfer, and absorption efficiencies, the results suggest that a 4-month-old infant could absorb up to 4 microg of lead a day (equivalent to a PbB level of up to about 2.4 microg/dl) by mouthing their fingers, about two-thirds of all exposure routes identified in this study. Estimates also suggest that lead uptake via inhalation accounts for about 0.5-3% of an infant's PbB at 5 microg/dl. If our estimates reflect real routes and values, the majority of the average PbB level of 6-month-old infants in Port Pirie during 2002 could potentially be accounted for by the normal infant and family behaviors observed in this study. While the current level of concern is 10 microg/dl, recent studies indicate no safe threshold for Pb exposure, and so interventions for reducing chronic low-level exposure are useful. We suggest that home-based interventions for reducing Pb exposure should focus on maintaining low Pb loadings on objects that are directly associated with an infant, and outside objects that have few transfer steps to the infant.
Authors:
Brenda D Kranz; David L Simon; Bianca G Leonardi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of exposure analysis and environmental epidemiology     Volume:  14     ISSN:  1053-4245     ISO Abbreviation:  J Expo Anal Environ Epidemiol     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-07-15     Completed Date:  2005-05-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111438     Medline TA:  J Expo Anal Environ Epidemiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  300-11     Citation Subset:  IM    
Affiliation:
Port Pirie Lead Implementation Program, Environmental Health Service, Department of Human Services, PO Box 6 Rundle Mall, Adelaide SA 5000, Australia.
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MeSH Terms
Descriptor/Qualifier:
Cohort Studies
Environmental Exposure / adverse effects*
Female
Fingers
Fingersucking / adverse effects
Humans
Infant
Infant Behavior*
Infant, Newborn
Inhalation
Lead / administration & dosage*,  blood
Male
Metallurgy
South Australia
Sucking Behavior*
Chemical
Reg. No./Substance:
7439-92-1/Lead

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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