| The behavior after intravenous injection in mice of multiwalled carbon nanotube / Fe(3)O(4) hybrid MRI contrast agents. | |
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MedLine Citation:
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PMID: 21459436 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Fe(3)O(4) nanoparticles were in situ loaded on the surface of multiwalled carbon nanotubes (MWCNTs) by a solvothermal method using diethylene glycol and diethanolamine as solvents and complexing agents. The as-prepared MWCNT/Fe(3)O(4) hybrids exhibited excellent hydrophilicity, superparamagnetic property at room temperature, and a high T(2) relaxivity of 175.5 mM(-1) s(-1) in aqueous solutions. In vitro experiments revealed that MWCNT/Fe(3)O(4) had an excellent magnetic resonance imaging (MRI) enhancement effect on cancer cells, and importantly, they displayed low cytotoxicity and neglectable hemolytic activity. After intravenous administration, the T(2)-weighted MRI signal in the liver and spleen of mice decreased significantly, suggesting the potential application of the hybrids as MRI contrast agents. The organ biodistribution studies, histological analyses and elimination investigations showed that the hybrids were uptaken by the liver, lung and spleen after intravenous injection, and could be excreted from the liver and kidney. |
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Authors:
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Huixia Wu; Gang Liu; Yeming Zhuang; Dongmei Wu; Haoqiang Zhang; Hong Yang; He Hu; Shiping Yang |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-1 |
Journal Detail:
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Title: Biomaterials Volume: - ISSN: 1878-5905 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8100316 Medline TA: Biomaterials Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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The Key Laboratory of Resource Chemistry of Ministry of Education, College of Life and Environmental Science, Shanghai Normal University, 100 Guilin Road, Shanghai 200234, P. R. China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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