Document Detail


The basomedial hypothalamus modulates the ventilatory response to hypoxia in neonatal rats.
MedLine Citation:
PMID:  12646729     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We sought to examine the role of the basomedial hypothalamus in the regulation of breathing in neonatal rats. Small basomedial hypothalamic lesions were produced by a lesioning agent, goldthioglucose, in 5-d-old male rat pups, and 2 d later, baseline ventilation and the ventilatory responses to hypoxia and hypercapnia were examined. When compared with vehicle-injected controls, goldthioglucose-lesioned rat pups had a significantly slower respiratory rate and longer expiratory time at baseline. Lesioned rats displayed an impaired increase in breathing frequency in response to hypoxia, and augmented increases in tidal volume and respiratory drive (the ratio of tidal volume to inspiratory time) during hypoxia relative to controls. Hypercapnic responses were not affected. These data demonstrate that cells in a restricted area of the hypothalamus specifically influence the respiratory response to hypoxia.
Authors:
Ismail A Dreshaj; Musa A Haxhiu; Richard J Martin; John K Young
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2003-03-19
Journal Detail:
Title:  Pediatric research     Volume:  53     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-06-02     Completed Date:  2004-01-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  945-9     Citation Subset:  IM    
Affiliation:
Department Pediatrics, Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, OH, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anoxia / physiopathology*
Hypothalamus / physiopathology*
Male
Rats
Rats, Sprague-Dawley
Respiration*
Grant Support
ID/Acronym/Agency:
1 U54 NS39407/NS/NINDS NIH HHS; HL 50527/HL/NHLBI NIH HHS; HL 62527/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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