| The basolateral amygdala mediates the effects of cues associated with meal interruption on feeding behavior. | |
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MedLine Citation:
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PMID: 20171956 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Considerable evidence shows that environmental cues that signal food delivery when rats are food-deprived can substantially potentiate feeding later when rats are food-sated. Similarly, cues associated with meal interruption, food removal or impending food scarcity may also induce increased eating. For example, after learning the association between a discrete "interruption" stimulus and the unexpected termination of food trials, sated rats show enhanced food consumption when exposed to that stimulus. In Experiment 1, unlike sham-lesioned controls, rats with bilateral excitotoxic lesions of the basolateral amygdala (BLA) failed to display such cue-potentiated feeding. In Experiment 2, potentiation of feeding by an interruption signal was found to be food-specific. That is, a stimulus that signaled interruption of trials with one food but not trials with a second food later only facilitated consumption of the first food. These studies extend our knowledge of the psychological and neural processes underlying cue-induced feeding. Understanding these mechanisms may contribute our understanding of the etiology and treatment of binge eating disorders. |
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Authors:
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Ezequiel M Galarce; Michael A McDannald; Peter C Holland |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-02-19 |
Journal Detail:
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Title: Brain research Volume: 1350 ISSN: 1872-6240 ISO Abbreviation: Brain Res. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-23 Completed Date: 2010-12-06 Revised Date: 2013-05-30 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 112-22 Citation Subset: IM |
Copyright Information:
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2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Johns Hopkins University, USA. ezequiel_galarce@dfci.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amygdala
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physiology* Analysis of Variance Animals Conditioning, Classical / physiology* Cues Extinction, Psychological / physiology* Feeding Behavior / physiology* Male Rats Rats, Long-Evans |
| Grant Support | |
ID/Acronym/Agency:
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MH53667/MH/NIMH NIH HHS; MH65879/MH/NIMH NIH HHS; R01 MH065879-05/MH/NIMH NIH HHS; R37 MH053667-13/MH/NIMH NIH HHS; R37 MH053667-16/MH/NIMH NIH HHS |
| Comments/Corrections | |
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