Document Detail


The basolateral amygdala mediates the effects of cues associated with meal interruption on feeding behavior.
MedLine Citation:
PMID:  20171956     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Considerable evidence shows that environmental cues that signal food delivery when rats are food-deprived can substantially potentiate feeding later when rats are food-sated. Similarly, cues associated with meal interruption, food removal or impending food scarcity may also induce increased eating. For example, after learning the association between a discrete "interruption" stimulus and the unexpected termination of food trials, sated rats show enhanced food consumption when exposed to that stimulus. In Experiment 1, unlike sham-lesioned controls, rats with bilateral excitotoxic lesions of the basolateral amygdala (BLA) failed to display such cue-potentiated feeding. In Experiment 2, potentiation of feeding by an interruption signal was found to be food-specific. That is, a stimulus that signaled interruption of trials with one food but not trials with a second food later only facilitated consumption of the first food. These studies extend our knowledge of the psychological and neural processes underlying cue-induced feeding. Understanding these mechanisms may contribute our understanding of the etiology and treatment of binge eating disorders.
Authors:
Ezequiel M Galarce; Michael A McDannald; Peter C Holland
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-02-19
Journal Detail:
Title:  Brain research     Volume:  1350     ISSN:  1872-6240     ISO Abbreviation:  Brain Res.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-23     Completed Date:  2010-12-06     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  112-22     Citation Subset:  IM    
Copyright Information:
2010 Elsevier B.V. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Amygdala / physiology*
Analysis of Variance
Animals
Conditioning, Classical / physiology*
Cues
Extinction, Psychological / physiology*
Feeding Behavior / physiology*
Male
Rats
Rats, Long-Evans
Grant Support
ID/Acronym/Agency:
MH53667/MH/NIMH NIH HHS; MH65879/MH/NIMH NIH HHS; R01 MH065879/MH/NIMH NIH HHS; R01 MH065879-05/MH/NIMH NIH HHS; R37 MH053667/MH/NIMH NIH HHS; R37 MH053667-13/MH/NIMH NIH HHS
Comments/Corrections

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