Document Detail


The basis for the increase in factor VIII procoagulant activity during exercise.
MedLine Citation:
PMID:  6405498     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied the effect of acute exercise on the ability of thrombin to activate plasma factor VIII (FVIII) activity in 20 healthy males. The subject showed an average exercise-related increase in FVIII activity of 54.5 +/- 8.2% over pre-exercise FVIII activity (p less than 0.001). When exposed to the same concentration of thrombin, post-exercise FVIII activity showed greater enhancement than pre-exercise FVIII activity: 157.1 +/- 12.8% increase in activity versus 117.3 +/- 9.9%, respectively (p less than 0.01). The degree of the potentiated thrombin effect in post-exercise samples relative to pre-exercise samples was linearly correlated with the degree of the exercise-related increase in FVIII activity. Taken together with our previous observations that the extent of thrombin enhancement of FVIII activity varies inversely with the mole ratio of FVIII/von Willebrand factor subunits to thrombin, these findings imply that release of FVIII does not occur during exercise, and that the exercise-related increase in FVIII activity results primarily, if not completely, from activation of already circulating but inactive FVIII.
Authors:
R G Kopitsky; M E Switzer; R S Williams; P A McKee
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  49     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  1983 Feb 
Date Detail:
Created Date:  1983-06-10     Completed Date:  1983-06-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  53-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Factor VIII / metabolism*
Humans
Male
Middle Aged
Physical Exertion*
Thrombin / pharmacology
Grant Support
ID/Acronym/Agency:
HL 15615/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
9001-27-8/Factor VIII; EC 3.4.21.5/Thrombin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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