Document Detail

A basic helix-loop-helix transcription factor controls cell growth and size in root hairs.
MedLine Citation:
PMID:  20139979     Owner:  NLM     Status:  MEDLINE    
Postmitotic cell growth defines cell shape and size during development. However, the mechanisms regulating postmitotic cell growth in plants remain unknown. Here we report the discovery of a basic helix-loop-helix (bHLH) transcription factor called RSL4 (ROOT HAIR DEFECTIVE 6-LIKE 4) that is sufficient to promote postmitotic cell growth in Arabidopsis thaliana root-hair cells. Loss of RSL4 function resulted in the development of very short root hairs. In contrast, constitutive RSL4 expression programmed constitutive growth, resulting in the formation of very long root hairs. Hair-cell growth signals, such as auxin and low phosphate availability, modulate hair cell extension by regulating RSL4 transcript and protein levels. RSL4 is thus a regulator of growth that integrates endogenous developmental and exogenous environmental signals that together control postmitotic growth in root hairs. The control of postmitotic growth by transcription factors may represent a general mechanism for regulating cell size across diverse organisms.
Keke Yi; Benoît Menand; Elizabeth Bell; Liam Dolan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-07
Journal Detail:
Title:  Nature genetics     Volume:  42     ISSN:  1546-1718     ISO Abbreviation:  Nat. Genet.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-24     Completed Date:  2010-04-15     Revised Date:  2014-10-14    
Medline Journal Info:
Nlm Unique ID:  9216904     Medline TA:  Nat Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  264-7     Citation Subset:  IM    
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MeSH Terms
Arabidopsis / cytology,  genetics*,  growth & development*
Arabidopsis Proteins / genetics,  metabolism,  physiology
Basic Helix-Loop-Helix Transcription Factors / genetics,  physiology*
Cell Proliferation*
Cell Size*
Cycloheximide / pharmacology
Dexamethasone / pharmacology
Gene Expression Regulation, Developmental / drug effects
Gene Expression Regulation, Plant / drug effects
Indoleacetic Acids / pharmacology
Plant Growth Regulators / pharmacology
Plant Roots / genetics,  growth & development*,  metabolism
Plants, Genetically Modified
Protein Synthesis Inhibitors / pharmacology
Grant Support
BBS/E/J/00000168//Biotechnology and Biological Sciences Research Council
Reg. No./Substance:
0/Arabidopsis Proteins; 0/Basic Helix-Loop-Helix Transcription Factors; 0/Indoleacetic Acids; 0/Plant Growth Regulators; 0/Protein Synthesis Inhibitors; 0/RSL4 protein, Arabidopsis; 7S5I7G3JQL/Dexamethasone; 98600C0908/Cycloheximide

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