| A bad rap: Rap1 signaling and oncogenesis. | |
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MedLine Citation:
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PMID: 12892706 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the paper by Ishida et al. in this issue of Cancer Cell, the authors report the results of targeted inactivation of a Rap1-specific GTPase-activating protein (GAP) gene, called SPA-1, in mice. Rap1 hyperactivation was observed in hematopoietic cells, which led over time to features associated with symptoms typical of human myeloid dyslastic and myeloid proliferative diseases. The authors present additional data showing that the level of Rap1 activation is important for regulating myelopoiesis and that, in the right context, can deliver an oncogenic signal. |
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Authors:
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David A Largaespada |
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Publication Detail:
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Type: Comment; Editorial |
Journal Detail:
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Title: Cancer cell Volume: 4 ISSN: 1535-6108 ISO Abbreviation: Cancer Cell Publication Date: 2003 Jul |
Date Detail:
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Created Date: 2003-08-01 Completed Date: 2004-03-09 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 101130617 Medline TA: Cancer Cell Country: United States |
Other Details:
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Languages: eng Pagination: 3-4 Citation Subset: IM |
Affiliation:
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University of Minnesota Cancer Center, 6-160 Jackson Hall, 321 Church Street S.E., Minneapolis, MN 55455, USA. larga002@tc.umn.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Transformation, Neoplastic / pathology* GTPase-Activating Proteins* Gene Expression Regulation, Leukemic* Humans Mice Mice, Knockout Myeloproliferative Disorders / genetics*, metabolism, pathology Nuclear Proteins / genetics, physiology* Signal Transduction* rap1 GTP-Binding Proteins / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/GTPase-Activating Proteins; 0/Nuclear Proteins; 0/SIPA1 protein, human; 0/Sipa1 protein, mouse; EC 3.6.5.2/rap1 GTP-Binding Proteins |
| Comments/Corrections | |
Comment On:
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Cancer Cell. 2003 Jul;4(1):55-65
[PMID:
12892713
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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