Document Detail

A bad rap: Rap1 signaling and oncogenesis.
MedLine Citation:
PMID:  12892706     Owner:  NLM     Status:  MEDLINE    
In the paper by Ishida et al. in this issue of Cancer Cell, the authors report the results of targeted inactivation of a Rap1-specific GTPase-activating protein (GAP) gene, called SPA-1, in mice. Rap1 hyperactivation was observed in hematopoietic cells, which led over time to features associated with symptoms typical of human myeloid dyslastic and myeloid proliferative diseases. The authors present additional data showing that the level of Rap1 activation is important for regulating myelopoiesis and that, in the right context, can deliver an oncogenic signal.
David A Largaespada
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Publication Detail:
Type:  Comment; Editorial    
Journal Detail:
Title:  Cancer cell     Volume:  4     ISSN:  1535-6108     ISO Abbreviation:  Cancer Cell     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-08-01     Completed Date:  2004-03-09     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  101130617     Medline TA:  Cancer Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3-4     Citation Subset:  IM    
University of Minnesota Cancer Center, 6-160 Jackson Hall, 321 Church Street S.E., Minneapolis, MN 55455, USA.
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MeSH Terms
Cell Transformation, Neoplastic / pathology*
GTPase-Activating Proteins*
Gene Expression Regulation, Leukemic*
Mice, Knockout
Myeloproliferative Disorders / genetics*,  metabolism,  pathology
Nuclear Proteins / genetics,  physiology*
Signal Transduction*
rap1 GTP-Binding Proteins / metabolism*
Reg. No./Substance:
0/GTPase-Activating Proteins; 0/Nuclear Proteins; 0/SIPA1 protein, human; 0/Sipa1 protein, mouse; EC GTP-Binding Proteins
Comment On:
Cancer Cell. 2003 Jul;4(1):55-65   [PMID:  12892713 ]

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