Document Detail


The bacterial nucleoid: nature, dynamics and sister segregation.
MedLine Citation:
PMID:  25460806     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Recent studies reveal that the bacterial nucleoid has a defined, self-adherent shape and an underlying longitudinal organization and comprises a viscoelastic matrix. Within this shape, mobility is enhanced by ATP-dependent processes and individual loci can undergo ballistic off-equilibrium movements. In Escherichia coli, two global dynamic nucleoid behaviors emerge pointing to nucleoid-wide accumulation and relief of internal stress. Sister segregation begins with local splitting of individual loci, which is delayed at origin, terminus and specialized interstitial snap regions. Globally, as studied in several systems, segregation is a multi-step process in which internal nucleoid state plays critical roles that involve both compaction and expansion. The origin and terminus regions undergo specialized programs partially driven by complex ATP burning mechanisms such as a ParAB Brownian ratchet and a septum-associated FtsK motor. These recent findings reveal strong, direct parallels among events in different systems and between bacterial nucleoids and mammalian chromosomes with respect to physical properties, internal organization and dynamic behaviors.
Authors:
Nancy Kleckner; Jay K Fisher; Mathieu Stouf; Martin A White; David Bates; Guillaume Witz
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Publication Detail:
Type:  REVIEW     Date:  2014-11-5
Journal Detail:
Title:  Current opinion in microbiology     Volume:  22C     ISSN:  1879-0364     ISO Abbreviation:  Curr. Opin. Microbiol.     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-12-2     Completed Date:  -     Revised Date:  2014-12-3    
Medline Journal Info:
Nlm Unique ID:  9815056     Medline TA:  Curr Opin Microbiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  127-137     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Ltd. All rights reserved.
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