Document Detail

The bacterial metabolism of 2,4-xylenol.
MedLine Citation:
PMID:  4387388     Owner:  NLM     Status:  MEDLINE    
1. Measurements of the rates of oxidation of various compounds by a fluorescent Pseudomonas indicated that metabolism of 2,4-xylenol was initiated by oxidation of the methyl group para to the hydroxyl group. 2. 4-Hydroxy-3-methylbenzoic acid was isolated as the product of oxidation of 2,4-xylenol by cells inhibited with alphaalpha'-bipyridyl. 3. 4-Hydroxyisophthalic acid accumulated at low oxygen concentrations when either 2,4-xylenol or 4-hydroxy-3-methylbenzoic acid was oxidized by cells grown with 2,4-xylenol. 4. When supplemented with NADH, but not with NADPH, cell extracts oxidized 4-hydroxy-3-methylbenzoic acid readily. 2-Hydroxy-5-methylbenzoic acid was not oxidized. 5. Both 4-hydroxyisophthalic acid and p-hydroxybenzoic acid were oxidized to beta-oxoadipic acid by cell extracts supplemented with either NADH or NADPH. 4,5-Dihydroxyisophthalic acid was not oxidized. 6. From measurements of oxygen consumed and carbon dioxide evolved it was concluded that protocatechuic acid is an intermediate in the conversion of 4-hydroxyisophthalic acid into beta-oxoadipic acid.
P J Chapman; D J Hopper
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Biochemical journal     Volume:  110     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1968 Dec 
Date Detail:
Created Date:  1969-02-17     Completed Date:  1969-02-17     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  491-8     Citation Subset:  IM    
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MeSH Terms
Adipic Acids / metabolism
Benzoates / metabolism
NAD / metabolism
NADP / metabolism
Phthalic Acids / metabolism
Pseudomonas / metabolism*
Xylenes / metabolism*
Reg. No./Substance:
0/Adipic Acids; 0/Benzoates; 0/Phthalic Acids; 0/Xylenes; 53-59-8/NADP; 53-84-9/NAD

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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