Document Detail

The bacterial etiology of preterm birth.
MedLine Citation:
PMID:  22794142     Owner:  NLM     Status:  In-Data-Review    
Preterm birth is the leading cause of infant morbidity and mortality. Very preterm births, those occurring before 32 completed weeks of gestation, are associated with the greatest risks. The leading cause of very preterm birth is intrauterine infection, which can lead to an inflammatory response that triggers labor or preterm premature rupture of membranes. How bacteria invade the uterine cavity, which is normally a sterile environment, and the reasons why different species vary in their capacity to induce inflammation and preterm birth are still incompletely understood. However, advanced techniques that circumvent the need for cultivating bacteria, deep sequence analysis that allows for the comprehensive characterization of the microbiome of a given body site and detection of low-prevalence species, and transcriptomics and metabolomics approaches that shed light on the host response to bacterial invasion are all providing a more complete picture of the progression from vaginal colonization to uterine invasion to preterm labor and preterm birth.
Kimberly K Jefferson
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in applied microbiology     Volume:  80     ISSN:  0065-2164     ISO Abbreviation:  Adv. Appl. Microbiol.     Publication Date:  2012  
Date Detail:
Created Date:  2012-07-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370413     Medline TA:  Adv Appl Microbiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-22     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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