Document Detail

The bacterial chromosome.
MedLine Citation:
PMID:  18365861     Owner:  NLM     Status:  MEDLINE    
Bacteria represent the vast majority of biological diversity found on Earth. In this review, we focus on selected aspects of their genetic material, those providing insight into structural, functional, dynamic, and evolutionary aspects of their genomes. Bacterial chromosomes are far more dynamic than previously realized, and dozens of mechanisms giving rise to genomic plasticity are now understood. Maturation of the genomics era has provided the tools for unraveling the interwoven details of DNA structure/function relationships that provide a basis for organismal diversity. Some of the most throughly understood processes that underlie the dynamics of genomic structure and function in prokaryotes are examined.
Milton H Saier
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Critical reviews in biochemistry and molecular biology     Volume:  43     ISSN:  1549-7798     ISO Abbreviation:  Crit. Rev. Biochem. Mol. Biol.     Publication Date:    2008 Mar-Apr
Date Detail:
Created Date:  2008-03-27     Completed Date:  2008-04-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8903774     Medline TA:  Crit Rev Biochem Mol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  89-134     Citation Subset:  IM    
Division of Biological Sciences, University of California at San Diego, La Jolla, California 92093-0116, USA.
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MeSH Terms
Base Sequence
Chromosomes, Bacterial / genetics*,  metabolism*
DNA, Bacterial / genetics
DNA, Superhelical / genetics
Escherichia coli / genetics*
Gene Rearrangement
Molecular Sequence Data
Mutation / genetics
Grant Support
Reg. No./Substance:
0/DNA, Bacterial; 0/DNA, Superhelical

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