| The bacterial chromosome. | |
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MedLine Citation:
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PMID: 18365861 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bacteria represent the vast majority of biological diversity found on Earth. In this review, we focus on selected aspects of their genetic material, those providing insight into structural, functional, dynamic, and evolutionary aspects of their genomes. Bacterial chromosomes are far more dynamic than previously realized, and dozens of mechanisms giving rise to genomic plasticity are now understood. Maturation of the genomics era has provided the tools for unraveling the interwoven details of DNA structure/function relationships that provide a basis for organismal diversity. Some of the most throughly understood processes that underlie the dynamics of genomic structure and function in prokaryotes are examined. |
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Authors:
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Milton H Saier |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Critical reviews in biochemistry and molecular biology Volume: 43 ISSN: 1549-7798 ISO Abbreviation: Crit. Rev. Biochem. Mol. Biol. Publication Date: 2008 Mar-Apr |
Date Detail:
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Created Date: 2008-03-27 Completed Date: 2008-04-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8903774 Medline TA: Crit Rev Biochem Mol Biol Country: United States |
Other Details:
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Languages: eng Pagination: 89-134 Citation Subset: IM |
Affiliation:
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Division of Biological Sciences, University of California at San Diego, La Jolla, California 92093-0116, USA. msaier@ucsd.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Base Sequence Chromosomes, Bacterial / genetics*, metabolism* DNA, Bacterial / genetics DNA, Superhelical / genetics Escherichia coli / genetics* Gene Rearrangement Molecular Sequence Data Mutation / genetics |
| Grant Support | |
ID/Acronym/Agency:
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GM 077402/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/DNA, Bacterial; 0/DNA, Superhelical |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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