| A bacterial cell-cycle regulatory network operating in time and space. | |
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MedLine Citation:
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PMID: 14512618 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Transcriptional regulatory circuits provide only a fraction of the signaling pathways and regulatory mechanisms that control the bacterial cell cycle. The CtrA regulatory network, important in control of the Caulobacter cell cycle, illustrates the critical role of nontranscriptional pathways and temporally and spatially localized regulatory proteins. The system architecture of Caulobacter cell-cycle control involves top-down control of modular functions by a small number of master regulatory proteins with cross-module signaling coordinating the overall process. Modeling the cell cycle probably requires a top-down modeling approach and a hybrid control system modeling paradigm to treat its combined discrete and continuous characteristics. |
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Authors:
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Harley H McAdams; Lucy Shapiro |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 301 ISSN: 1095-9203 ISO Abbreviation: Science Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-09-26 Completed Date: 2003-10-27 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: United States |
Other Details:
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Languages: eng Pagination: 1874-7 Citation Subset: IM |
Affiliation:
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Department of Developmental Biology, Stanford University School of Medicine, B300 Beckman Center, Stanford, CA 94305, USA. hmcadams@stanford.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bacterial Physiological Phenomena* Bacterial Proteins / metabolism Caulobacter / cytology, genetics, growth & development, physiology* Cell Cycle* Cell Polarity DNA-Binding Proteins / genetics, metabolism* Flagella / metabolism Gene Expression Regulation, Bacterial Models, Biological Signal Transduction Transcription Factors / genetics, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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GM32506/5120 M2/GM/NIGMS NIH HHS; GM51426/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Proteins; 0/CtrA protein, Caulobacter; 0/DNA-Binding Proteins; 0/Transcription Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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