Document Detail

A bHLH transcriptional network regulating the specification of retinal ganglion cells.
MedLine Citation:
PMID:  16079155     Owner:  NLM     Status:  MEDLINE    
In the developing retina, the production of ganglion cells is dependent on the proneural proteins NGN2 and ATH5, whose activities define stages along the pathway converting progenitors into newborn neurons. Crossregulatory interactions between NGN2, ATH5 and HES1 maintain the uncommitted status of ATH5-expressing cells during progenitor patterning, and later on regulate the transition from competence to cell fate commitment. Prior to exiting the cell cycle, a subset of progenitors is selected from the pool of ATH5-expressing cells to go through a crucial step in the acquisition of a definitive retinal ganglion cell fate. The selected cells are those in which the upregulation of NGN2, the downregulation of HES1 and the autostimulation of ATH5 are coordinated with the progression of progenitors through the last cell cycle. This coordinated pattern initiates the transcription of ganglion cell-specific traits and determines the size of the ganglion cell population.
Lidia Matter-Sadzinski; Monika Puzianowska-Kuznicka; Julio Hernandez; Marc Ballivet; Jean-Marc Matter
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-08-03
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  132     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-08-15     Completed Date:  2005-11-01     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  3907-21     Citation Subset:  IM    
University of Lausanne, Eye Hospital Jules Gonin and Institute for Research in Ophthalmology, 15 avenue de France, 1004 Lausanne, Switzerland.
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MeSH Terms
Avian Proteins / genetics,  metabolism
Basic Helix-Loop-Helix Transcription Factors
Body Patterning
Cell Cycle
Cell Differentiation*
Cell Lineage*
Cell Proliferation
Cells, Cultured
Chick Embryo
DNA-Binding Proteins / genetics,  metabolism*
Epithelium / embryology,  metabolism
Gene Expression Regulation, Developmental*
Growth Substances / genetics,  metabolism
Promoter Regions, Genetic / genetics
RNA, Messenger / genetics,  metabolism
Retinal Ganglion Cells / cytology*,  metabolism*
S Phase
Stem Cells / cytology,  metabolism
Time Factors
Transcription Factors / genetics,  metabolism*
Transcription, Genetic / genetics*
Reg. No./Substance:
0/Avian Proteins; 0/Basic Helix-Loop-Helix Transcription Factors; 0/DNA-Binding Proteins; 0/Growth Substances; 0/RNA, Messenger; 0/Transcription Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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