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bHLH-Orange Transcription Factors in Development and Cancer.
MedLine Citation:
PMID:  23641148     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Basic helix-loop-helix (bHLH) proteins are a large superfamily of transcription factors that play critical roles in many physiological processes including cellular differentiation, cell cycle arrest and apoptosis. Based on structural and phylogenetic analysis, mammalian bHLH-Orange (bHLH-O) proteins, which constitute the repressor family of bHLH factors, can be grouped into four subfamilies: Hes, Hey, Helt and Stra13/Dec. In addition to the bHLH domain that mediates DNA-binding and protein dimerization, all members of this family are characterized by a distinctive motif called the "Orange domain" which is present exclusively in these factors. Genetic studies using targeted mutagenesis in mice have revealed essential roles for many bHLH-O genes in embryonic development, cell fate decisions, differentiation of a number of cell types and in apoptosis. Furthermore, growing evidence of crosstalk between bHLH-O proteins with the tumor suppressors p53 and hypoxia-inducible factor, have started to shed light on their possible roles in oncogenesis. Consistently, deregulated expression of several bHLH-O factors is associated with various human cancers. Here, we review the structure and biological functions of bHLH-O factors, and discuss recent studies that suggest a potential role for these factors in tumorigenesis and tumor progression.
Authors:
Hong Sun; Saghi Ghaffari; Reshma Taneja
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Publication Detail:
Type:  Journal Article     Date:  2007-12-10
Journal Detail:
Title:  Translational oncogenomics     Volume:  2     ISSN:  1177-2727     ISO Abbreviation:  Transl Oncogenomics     Publication Date:  2007  
Date Detail:
Created Date:  2013-05-03     Completed Date:  2013-05-06     Revised Date:  2013-05-13    
Medline Journal Info:
Nlm Unique ID:  101276050     Medline TA:  Transl Oncogenomics     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  107-20     Citation Subset:  -    
Affiliation:
Department of Molecular, Cell, and Developmental Biology, Mount Sinai School of Medicine, New York, NY. ; Nelson Institute of Environmental Medicine, NYU School of Medicine, Tuxedo, NY.
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