| Trimethoprim/Sulfamethoxazole and azithromycin combination therapy for ocular toxoplasmosis. | |
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MedLine Citation:
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PMID: 19657985 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate the efficacy and safety of trimethoprim/sulfamethoxazole and azithromycin combination for the treatment of ocular toxoplasmosis. METHODS: Nineteen ocular toxoplasmosis patients treated with trimethoprim/sulfamethoxazole and azithromycin +/- corticosteroid combination were retrospectively reviewed. Demographic data, clinical findings, the time interval until resolution of inflammation, recurrences, and drug side effects were collected. RESULTS: The mean follow-up time of the patients was 25.0 +/- 22.5 (range; 6 -66) months. Final visual acuity improved with a mean of 6 +/- 4 lines in 15 patients (78.9%). Inflammatory findings began to subside within 14.8 +/- 10.0 days. Three patients (15.8%) had recurrent attack. Only 1 patient (5.3%) had side effects from therapy. CONCLUSIONS: Trimethoprim/sulfamethoxazole and azithromycin combination is an effective and safe treatment modality for the treatment of ocular toxoplasmosis. |
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Authors:
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Alper Yazici; Pinar Cakar Ozdal; Ibrahim Taskintuna; Sevim Kavuncu; Gultekin Koklu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Ocular immunology and inflammation Volume: 17 ISSN: 1744-5078 ISO Abbreviation: Ocul. Immunol. Inflamm. Publication Date: 2009 Jul-Aug |
Date Detail:
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Created Date: 2009-08-06 Completed Date: 2009-10-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9312169 Medline TA: Ocul Immunol Inflamm Country: England |
Other Details:
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Languages: eng Pagination: 289-91 Citation Subset: IM |
Affiliation:
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Ulucanlar Eye Education and Research Hospital, Ankara, Turkey. lpryzc@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anti-Bacterial Agents / administration & dosage* Anti-Infective Agents / administration & dosage* Azithromycin / administration & dosage* Child Drug Therapy, Combination Female Follow-Up Studies Humans Macula Lutea Male Middle Aged Recurrence Steroids / administration & dosage Toxoplasmosis, Ocular / drug therapy*, physiopathology Trimethoprim-Sulfamethoxazole Combination / administration & dosage*, adverse effects Visual Acuity / drug effects Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Anti-Infective Agents; 0/Steroids; 8064-90-2/Trimethoprim-Sulfamethoxazole Combination; 83905-01-5/Azithromycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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