Document Detail

The awesome power of multiple model systems: interpreting the complex nature of spindle checkpoint signaling.
MedLine Citation:
PMID:  12062159     Owner:  NLM     Status:  MEDLINE    
The spindle checkpoint coordinates the cell biology of mitosis with cell-cycle progression. It ensures that sister-chromatid separation only takes place when all kinetochores have formed stable bipolar microtubule attachments. Here, we discuss recent advances in our understanding of what activates this checkpoint pathway, the molecular nature of the checkpoint signal and its mode of transmission, and how the checkpoint might be inactivated.
David N Millband; Leigh Campbell; Kevin G Hardwick
Related Documents :
18712789 - Kinesin-5 is not essential for mitotic spindle elongation in dictyostelium.
10559879 - Centrosome duplication in mammalian somatic cells requires e2f and cdk2-cyclin a.
15813749 - Requirement for microtubules and dynein motors in the earliest stages of peroxisome bio...
18524779 - Covalent binding to tubulin by isothiocyanates. a mechanism of cell growth arrest and a...
17227889 - Desmoplakin: an unexpected regulator of microtubule organization in the epidermis.
18239929 - Nedd1 expression as a marker of dynamic centrosomal localization during mouse embryonic...
1868459 - Inhibition of growth of mouse leukemic cell lines in vitro and in vivo by a monoclonal ...
20169399 - A natural compound, methyl angolensate, induces mitochondrial pathway of apoptosis in d...
20153499 - On the role of metabolic activity on the transport und deposition of pseudomonas fluore...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Trends in cell biology     Volume:  12     ISSN:  0962-8924     ISO Abbreviation:  Trends Cell Biol.     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-06-13     Completed Date:  2002-11-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9200566     Medline TA:  Trends Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  205-9     Citation Subset:  IM    
Wellcome Trust Centre for Cell Biology, University of Edinburgh, King's Buildings, Mayfield Road, UK EH9 3JR.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Microtubules / metabolism*
Mitotic Spindle Apparatus*
Models, Biological
Signal Transduction

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of 4-nonylphenol on gene expression of pituitary hormones in juvenile Atlantic salmon (Salmo...
Next Document:  RECKing MMP function: implications for cancer development.