Document Detail


The awesome power of multiple model systems: interpreting the complex nature of spindle checkpoint signaling.
MedLine Citation:
PMID:  12062159     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The spindle checkpoint coordinates the cell biology of mitosis with cell-cycle progression. It ensures that sister-chromatid separation only takes place when all kinetochores have formed stable bipolar microtubule attachments. Here, we discuss recent advances in our understanding of what activates this checkpoint pathway, the molecular nature of the checkpoint signal and its mode of transmission, and how the checkpoint might be inactivated.
Authors:
David N Millband; Leigh Campbell; Kevin G Hardwick
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Trends in cell biology     Volume:  12     ISSN:  0962-8924     ISO Abbreviation:  Trends Cell Biol.     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-06-13     Completed Date:  2002-11-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9200566     Medline TA:  Trends Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  205-9     Citation Subset:  IM    
Affiliation:
Wellcome Trust Centre for Cell Biology, University of Edinburgh, King's Buildings, Mayfield Road, UK EH9 3JR.
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MeSH Terms
Descriptor/Qualifier:
Anaphase
Animals
Humans
Kinetics
Metaphase
Microtubules / metabolism*
Mitosis
Mitotic Spindle Apparatus*
Models, Biological
Signal Transduction
Xenopus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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