Document Detail

An autopsy case report of annuloaortic ectasia with cardiac tamponade ruptured from an aneurysm of the right Valsalva sinus.
MedLine Citation:
PMID:  17646055     Owner:  NLM     Status:  MEDLINE    
Annuloaortic ectasia (AAE) is a clinicopathologic condition with primary or secondary dilatation of the aortic annulus and aneurysm of the proximal thoracic aorta, leading to aortic regurgitation. We herein report an autopsy case of a Japanese 57-year-old male with AAE who died of a cardiac tamponade rupture from the sinus of the right coronary. The wall of the aortic root, particularly that of the sinus of the right coronary Valsalva, underwent extensive fibrosis with loss or fragmentation of the elastic lamina in the medial layer and perforation directly into the pericardial space. The adventitia of the proximal aorta to the aortic arch was diffusely fibrotic with both acute and chronic hemorrhage and chronic inflammatory infiltrate. However, the ascending aortic media was largely intact, except for focal laminar necrosis at the center of the medial layer; no medial cystic necrosis, laminar necrosis, or mesoaortitis/panaortitis was present in the thoracic or abdominal aorta, nor in the main aortic branches, which was suggestive of Takayasu disease and giant cell arteritis. Thus, this patient was diagnosed to have idiopathic AAE with sustained peri-aortic hemorrhage, and he finally died of a cardiac tamponade resulting from an aneurysmal rupture.
Takaaki Fujii; Shinji Sumiyoshi; Takaomi Koga; Mari Nishizaka; Ryuichi Matsukawa; Hiroyuki Kuwano; Katsuo Sueishi
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2007-07-23
Journal Detail:
Title:  Pathology, research and practice     Volume:  203     ISSN:  0344-0338     ISO Abbreviation:  Pathol. Res. Pract.     Publication Date:  2007  
Date Detail:
Created Date:  2007-08-31     Completed Date:  2007-10-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  671-5     Citation Subset:  IM    
Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
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MeSH Terms
Aortic Aneurysm / complications,  diagnosis*,  pathology
Aortic Rupture / complications*,  etiology,  pathology
Aortic Valve Insufficiency / etiology*,  pathology
Aortitis / diagnosis
Cardiac Tamponade / etiology*,  pathology
Diagnosis, Differential
Dilatation, Pathologic
Fatal Outcome
Middle Aged
Sinus of Valsalva / pathology*
Takayasu Arteritis / diagnosis

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