Document Detail

An autopsy case of mitochondrial encephalomyopathy: biochemical and electron microscopic studies of the brain.
MedLine Citation:
PMID:  2844999     Owner:  NLM     Status:  MEDLINE    
A 29-year-old single woman had recurrent stroke-like episodes. She developed loss of consciousness, myoclonic seizures, and lactic acidosis. She died at the age of 30. A muscle biopsy study revealed mitochondrial myopathy, and the postmortem biochemical analysis demonstrated decreased cytochrome c oxidase activity in the skeletal muscles by 20% of normal control. The brain had multiple ischemic lesions in the cerebral cortex without major vascular occlusions. We present this case as an autopsy case of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) with a partial deficiency of cytochrome c oxidase. The analytical electron microscopic study of the calcified small vessels in the globus pallidus revealed increased calcium, phosphorus and iron. No accumulation of chromium, nickel or zinc was noted in this case, which was different from the previously reported cases of basal ganglia calcification.
M Kishi; Y Yamamura; T Kurihara; N Fukuhara; K Tsuruta; S Matsukura; T Hayashi; M Nakagawa; M Kuriyama
Related Documents :
9339869 - Childhood occipital epilepsy: seizure manifestations and electroencephalographic features.
24607199 - Annual acknowledgement of manuscript reviewers.
15805669 - Rosai-dorfman disease mimicking a sphenoid wing meningioma.
6412579 - Benign familial neonatal convulsions.
1739219 - Tonic status epilepticus: an unusual presentation of unresponsiveness.
15135169 - Neurosyphilis and status epilepticus: case report and literature review.
135509 - Cardiac involvement in the kugelbert-welander syndrome.
17218049 - Acute dystonia resulting from abrupt bupropion discontinuation.
20548889 - Diffuse cutaneous mastocytosis with generalized bullae.
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  86     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-11-04     Completed Date:  1988-11-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  31-40     Citation Subset:  IM    
Fourth Department of Medicine, Toho University, School of Medicine, Tokyo, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Brain / metabolism,  radiography,  ultrastructure*
Demyelinating Diseases / metabolism,  pathology*
Electron Transport Complex IV / metabolism*
Microscopy, Electron
Muscles / metabolism*,  pathology
Vacuoles / ultrastructure
Reg. No./Substance:
EC Transport Complex IV

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Regional distribution of the GABAA/benzodiazepine receptor (alpha subunit) mRNA in rat brain.
Next Document:  Non-lethal infection of aminergic reticular core neurons: age-dependent spread of ts mutant vesicula...