Document Detail


An autopsy case of mitochondrial encephalomyopathy: biochemical and electron microscopic studies of the brain.
MedLine Citation:
PMID:  2844999     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 29-year-old single woman had recurrent stroke-like episodes. She developed loss of consciousness, myoclonic seizures, and lactic acidosis. She died at the age of 30. A muscle biopsy study revealed mitochondrial myopathy, and the postmortem biochemical analysis demonstrated decreased cytochrome c oxidase activity in the skeletal muscles by 20% of normal control. The brain had multiple ischemic lesions in the cerebral cortex without major vascular occlusions. We present this case as an autopsy case of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) with a partial deficiency of cytochrome c oxidase. The analytical electron microscopic study of the calcified small vessels in the globus pallidus revealed increased calcium, phosphorus and iron. No accumulation of chromium, nickel or zinc was noted in this case, which was different from the previously reported cases of basal ganglia calcification.
Authors:
M Kishi; Y Yamamura; T Kurihara; N Fukuhara; K Tsuruta; S Matsukura; T Hayashi; M Nakagawa; M Kuriyama
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  86     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-11-04     Completed Date:  1988-11-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  31-40     Citation Subset:  IM    
Affiliation:
Fourth Department of Medicine, Toho University, School of Medicine, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Brain / metabolism,  radiography,  ultrastructure*
Demyelinating Diseases / metabolism,  pathology*
Electron Transport Complex IV / metabolism*
Female
Humans
Microscopy, Electron
Muscles / metabolism*,  pathology
Vacuoles / ultrastructure
Chemical
Reg. No./Substance:
EC 1.9.3.1/Electron Transport Complex IV

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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