| An autopsy case of hypertrophic cardiomyopathy with pathological findings suggesting chronic myocarditis. | |
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MedLine Citation:
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PMID: 8201786 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Myocardial fibrosis in patients with hypertrophic cardiomyopathy (HCM) may play an important role in the function and/or dimensions of the left ventricle. We present an autopsied case of HCM followed for 10 years. A 68-year-woman with HCM underwent trans-aortic myectomy of the interventricular septum in 1979. A significant amount of round cell infiltration, myocardial fibrosis and disarray were observed in the resected specimen. She experienced repeated admissions due to diabetes mellitus and congestive heart failure, and died of renal failure in 1989. An autopsy revealed extensive myocardial fibrosis and significant cell infiltration in the ventricular myocardium. The infiltrating cells were almost all lymphocytes, and the ratio of CD4 to CD8 was 3.8. This ratio was different from that of typical viral myocarditis. This case suggests that there may be an undefined inflammatory process causing fibrosis in HCM, in addition to the ischemia due to intramural small coronary artery stenosis. |
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Authors:
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H Kawano; S Kawai; T Nishijo; T Shirai; Y Inagaki; R Okada |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Japanese heart journal Volume: 35 ISSN: 0021-4868 ISO Abbreviation: Jpn Heart J Publication Date: 1994 Jan |
Date Detail:
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Created Date: 1994-07-05 Completed Date: 1994-07-05 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0401175 Medline TA: Jpn Heart J Country: JAPAN |
Other Details:
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Languages: eng Pagination: 95-105 Citation Subset: IM |
Affiliation:
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Research Laboratory for Cardiovascular Pathology, Juntendo University School of Medicine, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cardiomyopathy, Hypertrophic / complications*, diagnosis, pathology Chronic Disease Electrocardiography Female Humans Myocarditis / complications*, pathology Myocardium / pathology |
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