| An autopsy case of acute multiple sclerosis (Marburg's type) during pregnancy. | |
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MedLine Citation:
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PMID: 18342435 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report a case of a 9-month pregnant woman who presented acute psychiatric and neurological symptoms with extensive involvement of the white matter on MRI and no oligoclonal bands on CSF examination. Despite high doses of intravenous steroids, plasmapheresis and immunosuppressive drugs, a fatal outcome (coma) was noted 8 months later. Neuropathological examination confirmed the diagnosis of Marburg's type of multiple sclerosis showing sharp-edged lesions of demyelination, giant astrocytes, numerous macrophages and little perivascular inflammation. We discuss the definition and limits of the Marburg entity with reference to acute disseminated encephalomyelitis, impact of pregnancy, unusual MRI features, neuropathology and treatment. |
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Authors:
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F Letournel; J Cassereau; C Scherer-Gagou; I Bernard; A Mercat; F Gray; J Y Tanguy; I Richard-Crémieux; Th Jeanfaivre; A Barthelaix; F Dubas |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2008-03-14 |
Journal Detail:
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Title: Clinical neurology and neurosurgery Volume: 110 ISSN: 0303-8467 ISO Abbreviation: Clin Neurol Neurosurg Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-05-13 Completed Date: 2008-08-14 Revised Date: 2009-10-14 |
Medline Journal Info:
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Nlm Unique ID: 7502039 Medline TA: Clin Neurol Neurosurg Country: Netherlands |
Other Details:
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Languages: eng Pagination: 514-7 Citation Subset: IM |
Affiliation:
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UF de Neurobiologie et Neuropathologie, Département de Pathologie Cellulaire et Tissulaire, CHU, 4 rue Larrey, 49033 Angers, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Brain / pathology* Diagnosis, Differential Encephalomyelitis, Acute Disseminated / pathology* Fatal Outcome Female Humans Immunosuppression Magnetic Resonance Imaging Multiple Sclerosis / drug therapy, pathology* Plasmapheresis Pregnancy Pregnancy Complications / drug therapy, pathology* Steroids / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Steroids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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