Document Detail


The autophagy regulators Ambra1 and Beclin 1 are required for adult neurogenesis in the brain subventricular zone.
MedLine Citation:
PMID:  25188513     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Autophagy is a conserved proteolytic mechanism required for maintaining cellular homeostasis. The role of this process in vertebrate neural development is related to metabolic needs and stress responses, even though the importance of its progression has been observed in a number of circumstances, both in embryonic and in postnatal differentiating tissues. Here we show that the proautophagic proteins Ambra1 and Beclin 1, involved in the initial steps of autophagosome formation, are highly expressed in the adult subventricular zone (SVZ), whereas their downregulation in adult neural stem cells in vitro leads to a decrease in cell proliferation, an increase in basal apoptosis and an augmented sensitivity to DNA-damage-induced death. Further, Beclin 1 heterozygosis in vivo results in a significant reduction of proliferating cells and immature neurons in the SVZ, accompanied by a marked increase in apoptotic cell death. In sum, we propose that Ambra1- and Beclin 1-mediated autophagy plays a crucial role in adult neurogenesis, by controlling the survival of neural precursor cells.
Authors:
M Yazdankhah; S Farioli-Vecchioli; A B Tonchev; A Stoykova; F Cecconi
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Publication Detail:
Type:  Journal Article     Date:  2014-09-04
Journal Detail:
Title:  Cell death & disease     Volume:  5     ISSN:  2041-4889     ISO Abbreviation:  Cell Death Dis     Publication Date:  2014  
Date Detail:
Created Date:  2014-09-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101524092     Medline TA:  Cell Death Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  e1403     Citation Subset:  IM    
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