Document Detail

The autophagic pathway: a cell survival strategy against the bacterial pore-forming toxin Vibrio cholerae cytolysin.
MedLine Citation:
PMID:  17404497     Owner:  NLM     Status:  MEDLINE    
Vibrio cholerae is the causative agent of cholera in humans. In addition to the criticalvirulence factors cholera toxin and toxin coregulated pilus, V. cholerae secretes V.cholerae cytolysin (VCC), a pore-forming exotoxin able to induce cell lysis and extensivevacuolation. We have shown that this vacuolation is related to the activation of autophagyin response to VCC action. Furthermore, we found that the autophagic pathway wasrequired to protect cells upon VCC intoxication. Based on additional data presented here,we propose a model aimed to explain the mechanism of cell protection. We postulatethat VCC-induced autophagic vacuoles, which display features of multivesicular bodies and enclose the toxin, are implicated in cell defense through VCC degradation involvingfusion with lysosomes.
Héctor A Saka; Maximiliano G Gutiérrez; José L Bocco; María I Colombo
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Publication Detail:
Type:  Comment; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-07-19
Journal Detail:
Title:  Autophagy     Volume:  3     ISSN:  1554-8627     ISO Abbreviation:  Autophagy     Publication Date:    2007 Jul-Aug
Date Detail:
Created Date:  2007-05-31     Completed Date:  2007-08-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101265188     Medline TA:  Autophagy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  363-5     Citation Subset:  IM    
Departamento de Bioquímica Clínica, Centro de Investigaciones en Bioquímica Clínica e Inmunología (CONICET), Universidad Nacional de Córdoba, Córdoba, Argentina.
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MeSH Terms
Autophagy / physiology*
CHO Cells
Caco-2 Cells
Cell Survival / physiology
Lysosomes / metabolism
Membrane Glycoproteins / metabolism*,  ultrastructure
Models, Biological
Pore Forming Cytotoxic Proteins / metabolism*,  ultrastructure
Vacuoles / metabolism,  ultrastructure
Vibrio cholerae / pathogenicity,  physiology*
Reg. No./Substance:
0/Membrane Glycoproteins; 0/Pore Forming Cytotoxic Proteins; 126465-35-8/Perforin
Comment On:
Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1829-34   [PMID:  17267617 ]

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