| The autophagic pathway: a cell survival strategy against the bacterial pore-forming toxin Vibrio cholerae cytolysin. | |
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MedLine Citation:
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PMID: 17404497 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vibrio cholerae is the causative agent of cholera in humans. In addition to the criticalvirulence factors cholera toxin and toxin coregulated pilus, V. cholerae secretes V.cholerae cytolysin (VCC), a pore-forming exotoxin able to induce cell lysis and extensivevacuolation. We have shown that this vacuolation is related to the activation of autophagyin response to VCC action. Furthermore, we found that the autophagic pathway wasrequired to protect cells upon VCC intoxication. Based on additional data presented here,we propose a model aimed to explain the mechanism of cell protection. We postulatethat VCC-induced autophagic vacuoles, which display features of multivesicular bodies and enclose the toxin, are implicated in cell defense through VCC degradation involvingfusion with lysosomes. |
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Authors:
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Héctor A Saka; Maximiliano G Gutiérrez; José L Bocco; María I Colombo |
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Publication Detail:
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Type: Comment; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-07-19 |
Journal Detail:
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Title: Autophagy Volume: 3 ISSN: 1554-8627 ISO Abbreviation: Autophagy Publication Date: 2007 Jul-Aug |
Date Detail:
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Created Date: 2007-05-31 Completed Date: 2007-08-30 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101265188 Medline TA: Autophagy Country: United States |
Other Details:
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Languages: eng Pagination: 363-5 Citation Subset: IM |
Affiliation:
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Departamento de Bioquímica Clínica, Centro de Investigaciones en Bioquímica Clínica e Inmunología (CONICET), Universidad Nacional de Córdoba, Córdoba, Argentina. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autophagy / physiology* CHO Cells Caco-2 Cells Cell Survival / physiology Cricetinae Cricetulus Humans Lysosomes / metabolism Membrane Glycoproteins / metabolism*, ultrastructure Models, Biological Perforin Pore Forming Cytotoxic Proteins / metabolism*, ultrastructure Vacuoles / metabolism, ultrastructure Vibrio cholerae / pathogenicity, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Membrane Glycoproteins; 0/Pore Forming Cytotoxic Proteins; 126465-35-8/Perforin |
| Comments/Corrections | |
Comment On:
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Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1829-34
[PMID:
17267617
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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