Document Detail

The autonomic nervous system and pressure-natriuresis in cardiovascular-renal interactions in response to salt.
MedLine Citation:
PMID:  12357279     Owner:  NLM     Status:  MEDLINE    
The maintenance of cardiovascular homeostasis represents a balance of activities between of the heart, vascular system and the kidneys in the control of extracellular fluid volume and ultimately blood pressure. Any disturbance in the function of these organs can lead to hypertension and heart failure. Interaction between the cardiovascular and renal systems is exerted dynamically by the autonomic nervous system and humoral factors which together determine the slope of the pressure-natriuresis relationship. This allows the body to ensure that dietary sodium intake can be excreted efficiently without causing major changes in blood pressure. Autonomic control of the kidney is exerted via the renal sympathetic nerves modulating renin release, sodium reabsorption and renal haemodynamics. Epidemiological studies have suggested a weak relationship between the level of dietary sodium intake and the development of hypertension, the underlying mechanisms are uncertain. It is evident from experimental studies that an elevation in dietary sodium intake during the growing phase heightens neural control of blood pressure and the kidney partly due to an enhanced role of the brain renin-angiotensin system. The relationship between dietary sodium and the autonomic regulation of blood pressure and the kidney is increasingly recognised as important but is only poorly understood.
Edward J Johns
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Clinical autonomic research : official journal of the Clinical Autonomic Research Society     Volume:  12     ISSN:  0959-9851     ISO Abbreviation:  Clin. Auton. Res.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-10-01     Completed Date:  2003-04-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9106549     Medline TA:  Clin Auton Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  256-63     Citation Subset:  IM    
Department of Physiology, University College Cork, College Road, Cork, Ireland.
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MeSH Terms
Autonomic Nervous System / physiology*
Blood Pressure / physiology*
Cardiovascular Physiological Phenomena / drug effects*
Kidney / drug effects*,  physiology
Natriuresis / physiology*
Sodium Chloride, Dietary / pharmacology*
Reg. No./Substance:
0/Sodium Chloride, Dietary

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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