Document Detail

An automatic alignment tool to improve repeatability of left ventricular function and dyssynchrony parameters in serial gated myocardial perfusion SPECT studies.
MedLine Citation:
PMID:  23211996     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Left ventricular (LV) function and dyssynchrony parameters measured from serial gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) using blinded processing had a poorer repeatability than when manual side-by-side processing was used. The objective of this study was to validate whether an automatic alignment tool can reduce the variability of LV function and dyssynchrony parameters in serial gated SPECT MPI.
METHODS: Thirty patients who had undergone serial gated SPECT MPI were prospectively enrolled in this study. Thirty minutes after the first acquisition, each patient was repositioned and a gated SPECT MPI image was reacquired. The two data sets were first processed blinded from each other by the same technologist in different weeks. These processed data were then realigned by the automatic tool, and manual side-by-side processing was carried out. All processing methods used standard iterative reconstruction and Butterworth filtering. The Emory Cardiac Toolbox was used to measure the LV function and dyssynchrony parameters.
RESULTS: The automatic tool failed in one patient, who had a large, severe scar in the inferobasal wall. In the remaining 29 patients, the repeatability of the LV function and dyssynchrony parameters after automatic alignment was significantly improved from blinded processing and was comparable to manual side-by-side processing.
CONCLUSION: The automatic alignment tool can be an alternative method to manual side-by-side processing to improve the repeatability of LV function and dyssynchrony measurements by serial gated SPECT MPI.
Yanli Zhou; Tracy L Faber; Zenic Patel; Russell D Folks; Alice A Cheung; Ernest V Garcia; Prem Soman; Dianfu Li; Kejiang Cao; Ji Chen
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nuclear medicine communications     Volume:  34     ISSN:  1473-5628     ISO Abbreviation:  Nucl Med Commun     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2012-12-17     Completed Date:  2013-07-23     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  8201017     Medline TA:  Nucl Med Commun     Country:  England    
Other Details:
Languages:  eng     Pagination:  124-9     Citation Subset:  IM    
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MeSH Terms
Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography / methods*
Image Processing, Computer-Assisted / methods*
Middle Aged
Myocardial Perfusion Imaging / methods*
Reproducibility of Results
Time Factors
Tomography, Emission-Computed, Single-Photon / methods*
Ventricular Dysfunction, Left / radionuclide imaging*
Ventricular Function, Left*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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